کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2049203 1074120 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hip2 interacts with cyclin B1 and promotes its degradation through the ubiquitin proteasome pathway
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Hip2 interacts with cyclin B1 and promotes its degradation through the ubiquitin proteasome pathway
چکیده انگلیسی

Hip2, a ubiquitin conjugating enzyme, is involved in the suppression of cell death. The present study revealed that Hip2 regulates the stability of the apoptotic and cell cycle regulator cyclin B1. Hip2 was found to interact with cyclin B1 to promote its degradation through the ubiquitin proteasome pathway. As a result, Hip2 significantly blocked cell death induced by the cyclin B1 protein, suggesting that Hip2 is involved in the regulation of cyclin B1-mediated cell death.Structured summaryMINT-8045218, MINT-8045231: Hip2 (uniprotkb:P61086) physically interacts (MI:0915) with cyclin-B1 (uniprotkb:P14635) by pull down (MI:0096)

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 22, 19 November 2010, Pages 4505–4510
نویسندگان
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