کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2049320 1074123 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The urokinase receptor: Focused cell surface proteolysis, cell adhesion and signaling
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
The urokinase receptor: Focused cell surface proteolysis, cell adhesion and signaling
چکیده انگلیسی

Plasma membrane urokinase-type plasminogen activator (uPA)-receptor (uPAR) is a GPI-anchored protein that binds with high-affinity and activates the serine protease uPA, thus regulating proteolytic activity at the cell surface. In addition, uPAR is a signaling receptor that often does not require its protease ligand or its proteolytic function.uPAR is highly expressed during tissue reorganization, inflammation, and in virtually all human cancers. Since its discovery, in vitro and in vivo models, as well as retrospective clinical studies have shown that over-expression of components of the uPA/uPAR-system correlates with increased proliferation, migration, and invasion affecting the malignant phenotype of cancer. uPAR regulates the cells–extracellular matrix interactions promoting its degradation and turnover through the plasminogen activation cascade.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 9, 3 May 2010, Pages 1923–1930
نویسندگان
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