کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2049358 | 1074125 | 2010 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Solution structure of the carboxy-terminal Tudor domain from human Coilin
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Solution structure of the carboxy-terminal Tudor domain from human Coilin Solution structure of the carboxy-terminal Tudor domain from human Coilin](/preview/png/2049358.png)
چکیده انگلیسی
The Cajal body is a dynamic eukaryotic nuclear organelle that is known primarily as an organizational center for the assembly of snRNAs involved in transcript splicing. One of the most critical components of the Cajal body is the scaffolding protein, Coilin. Here, we demonstrate by NMR methods that the carboxy-terminal region contains a Tudor domain. The Tudor domain is atypical due to the presence of several unstructured loops, one greater than thirty amino acids in length. Tudor domains have been noted previously to bind DNA, RNA and modified amino acids. The absence of these sequence and structural signatures in the Coilin Tudor domain supporting these established functions suggests an alternative role.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 20, 22 October 2010, Pages 4351–4356
Journal: FEBS Letters - Volume 584, Issue 20, 22 October 2010, Pages 4351–4356
نویسندگان
Riya Shanbhag, Arwa Kurabi, Jamie J. Kwan, Logan W. Donaldson,