کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2049360 | 1074125 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The heterogeneous nuclear ribonucleoprotein K is important for Herpes simplex virus-1 propagation
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The heterogeneous nuclear ribonucleoprotein K is important for Herpes simplex virus-1 propagation The heterogeneous nuclear ribonucleoprotein K is important for Herpes simplex virus-1 propagation](/preview/png/2049360.png)
چکیده انگلیسی
The heterogeneous nuclear ribonucleoprotein (hnRNP) K is an evolutionarily conserved protein with roles in signal transduction and gene expression. An impact of hnRNP K on the life cycle of a broad range of viral pathogens was reported while functional data for herpesviruses were lacking. In this study we show that hnRNP K is important for Herpes simplex virus 1 egress. In absence of hnRNP K, viral entry, gene expression, viral DNA replication, and maturation of nuclear particles appear normal whereas release of infectious virions to the extracellular space was significantly affected. Our results indicate that hnRNP K has an impact on a late step of herpesviral propagation making it a potential antiviral target.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 20, 22 October 2010, Pages 4361–4365
Journal: FEBS Letters - Volume 584, Issue 20, 22 October 2010, Pages 4361–4365
نویسندگان
Tina Schmidt, Hannah Striebinger, Jürgen Haas, Susanne M. Bailer,