کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2049390 | 1074126 | 2009 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Interplay of CCR2 signaling and local shear force determines vein graft neointimal hyperplasia in vivo Interplay of CCR2 signaling and local shear force determines vein graft neointimal hyperplasia in vivo](/preview/png/2049390.png)
Leukocytes play a central role in vein graft neointimal hyperplasia, which is significantly augmented under low shear conditions. The current concept is that shear force regulates leukocyte adhesion predominately through up-regulation of chemokines and growth factors within the graft wall. Using rabbit and murine vein graft models, we demonstrate that CC chemokine receptor 2/monocyte chemoattractant protein-1 mediated monocyte recruitment and a low shear environment act synergistically to augment neointimal hyperplasia development and removal of either of the conditions leads to a significant reduction in neointimal thickening. We propose a novel concept that the shear stress response element phenotypically stems from the complex interplay of the biological and physical microenvironments.
Journal: FEBS Letters - Volume 583, Issue 21, 3 November 2009, Pages 3536–3540