کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2049459 | 1074128 | 2007 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Loss of putative tumor suppressor EI24/PIG8 confers resistance to etoposide Loss of putative tumor suppressor EI24/PIG8 confers resistance to etoposide](/preview/png/2049459.png)
Expression of p53-target gene EI24/PIG8 is lost in invasive breast cancers, suggesting that EI24/PIG8 is a tumor suppressor that prevents tumor spreading, and partially mediates p53-attributed tumor suppressor activity. EI24/PIG8 also has pro-apoptotic activity indicating that loss of EI24/PIG8 may modulate sensitivity to chemotherapy. Here it is demonstrated that suppression of EI24/PIG8 in fibroblasts and breast cancer cells significantly inhibits the apoptotic response to etoposide treatment. These findings suggest that loss of EI24/PIG8 contributes significantly to resistance of cells to chemotherapeutic agents that function through p53, and identify the EI24/PIG8 status as a potentially new prognostic marker of chemotherapy responsiveness.
Journal: FEBS Letters - Volume 581, Issue 28, 27 November 2007, Pages 5440–5444