کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2049503 1074130 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Focal adhesion disassembly requires clathrin-dependent endocytosis of integrins
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Focal adhesion disassembly requires clathrin-dependent endocytosis of integrins
چکیده انگلیسی

Cell migration requires the controlled disassembly of focal adhesions, but the underlying mechanisms remain poorly understood. Here, we show that adhesion turnover is mediated through dynamin- and clathrin-dependent endocytosis of activated β1 integrins. Consistent with this, clathrin and the clathrin adaptors AP-2 and disabled-2 (DAB2) distribute along with dynamin 2 to adhesion sites prior to adhesion disassembly. Moreover, knockdown of either dynamin 2 or both clathrin adaptors blocks β1 integrin internalization, leading to impaired focal adhesion disassembly and cell migration. Together, these results provide important insight into the mechanisms underlying adhesion disassembly and identify novel components of the disassembly pathway.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 583, Issue 8, 17 April 2009, Pages 1337–1343
نویسندگان
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