کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2049525 1074131 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Multiple recognition systems adopting four different glycotopes at the same domain for the Agaricus bisporus agglutinin–glycan interactions
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Multiple recognition systems adopting four different glycotopes at the same domain for the Agaricus bisporus agglutinin–glycan interactions
چکیده انگلیسی

For the GalNAcα1→ specific Agaricus bisporus agglutinin (ABA) from an edible mushroom, the mechanism of polyvalent Galβ1→3/4GlcNAcβ1→ complex in ABA–carbohydrate recognition has not been well defined since Gal and GlcNAc are weak ligands. By enzyme-linked lectinosorbent and inhibition assays, we show that the polyvalent Galβ1→3/4GlcNAcβ1→ in natural glycans also play vital roles in binding and we propose that four different intensities of glycotopes (Galβ1-3GalNAcα1-, GalNAcα1-Ser/Thr and Galβ1-3/4GlcNAcβ1-) construct three recognition systems at the same domain. This peculiar concept provides the most comprehensive mechanism for the attachment of ABA to target glycans and malignant cells at the molecular level.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 16, 20 August 2010, Pages 3561–3566
نویسندگان
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