کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2049529 | 1074131 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Apigenin inhibits larval growth of Caenorhabditis elegans through DAF-16 activation
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Apigenin inhibits larval growth of Caenorhabditis elegans through DAF-16 activation Apigenin inhibits larval growth of Caenorhabditis elegans through DAF-16 activation](/preview/png/2049529.png)
چکیده انگلیسی
Treatment of Caenorhabditis elegans with apigenin, 5,7,4′-trihydroxyflavone, induces larval growth inhibition. To understand the molecular basis of apigenin-induced larval growth inhibition, the effects of apigenin on DAF-16 activity were examined. DAF-16 was activated through nuclear translocation and the mRNA level of sod-3, one of the known DAF-16 target genes, was increased upon apigenin treatment. DAF-16 activity was required for the growth inhibition, since the larval growth retardation upon apigenin treatment was suppressed in daf-16 mutants. These results indicate that apigenin acts as a stressor that activates DAF-16, which in turn inhibits larval growth.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 16, 20 August 2010, Pages 3587–3591
Journal: FEBS Letters - Volume 584, Issue 16, 20 August 2010, Pages 3587–3591
نویسندگان
Ichiro Kawasaki, Myung-Hwan Jeong, Bong-Kyeong Oh, Yhong-Hee Shim,