کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2049532 | 1074131 | 2010 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The Drosophila homolog of methionine sulfoxide reductase A extends lifespan and increases nuclear localization of FOXO
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The Drosophila homolog of methionine sulfoxide reductase A extends lifespan and increases nuclear localization of FOXO The Drosophila homolog of methionine sulfoxide reductase A extends lifespan and increases nuclear localization of FOXO](/preview/png/2049532.png)
چکیده انگلیسی
Methionine sulfoxide reductase A (msrA) was previously found to increase resistance to oxidative stress and longevity in animals. We identified Drosophila msrA (dmsrA), a Drosophila homolog of human msrA, as a downstream effector of forkhead box O (FOXO) signaling in Drosophila, which enhances resistance to oxidative stress and increases survival under stressed conditions. Additionally, overexpression of dmsrA in neurons extended the lifespan of flies. Moreover, overexpression of dmsrA in fat body cells caused FOXO to translocate to the nucleus, implying that this possible positive feedback loop between dmsrA and FOXO could potentiate the antioxidant activity of dmsrA and increase the lifespan in Drosophila.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 16, 20 August 2010, Pages 3609–3614
Journal: FEBS Letters - Volume 584, Issue 16, 20 August 2010, Pages 3609–3614
نویسندگان
Hyewon Chung, Ae-kyeong Kim, Sun-Ah Jung, Si Wouk Kim, Kweon Yu, Joon H. Lee,