کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2049634 | 1074135 | 2008 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Testicular aging involves mitochondrial dysfunction as well as an increase in UCP2 levels and proton leak
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Testicular aging involves mitochondrial dysfunction as well as an increase in UCP2 levels and proton leak Testicular aging involves mitochondrial dysfunction as well as an increase in UCP2 levels and proton leak](/preview/png/2049634.png)
چکیده انگلیسی
To address the possibility that mitochondria are involved in the age-related loss of testicular function, we characterized mitochondrial bioenergetics in rat testis. A peak of mitochondrial functionality was detected in adult animals, with a decrease in both young and older animals. In the latter group a decrease in mitochondrial function was matched with an increase in proton leak and expression and activity of uncoupling protein 2 (UCP2), suggesting that proton leak may be involved in managing age-dependent mitochondrial dysfunction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 582, Issue 30, 24 December 2008, Pages 4191–4196
Journal: FEBS Letters - Volume 582, Issue 30, 24 December 2008, Pages 4191–4196
نویسندگان
Sandra Amaral, Paula Mota, Ana Sofia Rodrigues, Luís Martins, Paulo J. Oliveira, João Ramalho-Santos,