کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2049712 1074139 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biphasic effect of insulin on beta cell apoptosis depending on glucose deprivation
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Biphasic effect of insulin on beta cell apoptosis depending on glucose deprivation
چکیده انگلیسی

Insulin resistant states are associated with an increase in the beta cell mass and also high levels of circulating insulin. Ultimately the beta cells undergo a failure that leads to diabetes. At this stage, a question arises if those persistent high levels of circulating insulin may contribute to beta cell damage. To address this important issue, we submitted beta cells to a prolonged effect of increasing concentrations of insulin. We observed that a prolonged effect of high levels of insulin on the presence of serum (15–24 h) in glucose-deprived beta cells induced apoptosis. This apoptotic effect was both dose- and cycloheximide-dependent.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 582, Issue 28, 26 November 2008, Pages 3855–3860
نویسندگان
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