کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2049794 1074143 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lumcorin: A leucine-rich repeat 9-derived peptide from human lumican inhibiting melanoma cell migration
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Lumcorin: A leucine-rich repeat 9-derived peptide from human lumican inhibiting melanoma cell migration
چکیده انگلیسی

We previously showed that lumican decreases melanoma progression. The aim of the present study was to determine the active sequence of the lumican core protein responsible for the inhibition of melanoma cell migration. Using different recombinant and synthetic peptides derived from lumican, we localized an active site in the leucine-rich repeat 9 domain of the lumican core protein. We propose the name lumcorin (fragment of lumican core protein) for the active peptide derived from this site. Lumcorin was able to inhibit melanoma cell migration in vitro.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 583, Issue 18, 17 September 2009, Pages 3027–3032
نویسندگان
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