کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2049936 1074147 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Essentiality is an emergent property of metabolic network wiring
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Essentiality is an emergent property of metabolic network wiring
چکیده انگلیسی

The topological bases of essentiality in the yeast metabolic network from the perspective of double mutations are the subject of this study. A strong relationship between essentiality and the ‘missing alternative’ topological property is shown in terms of the presence of multiple genes synthesizing the same enzyme, supplementary enzymes participating in the same metabolic reaction, and availability of other pathways in the graph connecting the separated nodes after the knockouts.We demonstrate that the ‘missing alternative’ paradigm is sufficient to explain the generation of essentiality for double mutations in which each single deleted element is non-essential.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 13, 29 May 2007, Pages 2485–2489
نویسندگان
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