کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2049940 1074147 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neurexin-1 is required for synapse formation and larvae associative learning in Drosophila
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Neurexin-1 is required for synapse formation and larvae associative learning in Drosophila
چکیده انگلیسی

Neurexins are highly polymorphic cell-surface adhesive molecules in neurons. In cultured mammalian cell system, they were found to be involved in synaptogenesis. Here, we report for the first time that Drosophila neurexin is required for synapse formation and associative learning in larvae. Drosophila genome encodes a single functional neurexin (CG7050; Neurexin-1 or Nrx-1), which is a homolog of vertebrate α-neurexin. Neurexin-1 is expressed in central nervous system and highly enriched in synaptic regions of the ventral ganglion and brain. Neurexin-1 null mutants are viable and fertile, but have shortened lifespan. The synapse number is decreased in central nervous system in Neurexin-1 null mutants. In addition, Neurexin-1 null mutants exhibit associative learning defect in larvae.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 13, 29 May 2007, Pages 2509–2516
نویسندگان
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