کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2050018 | 1074150 | 2008 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inhibition of the glucosyltransferase activity of clostridial Rho/Ras-glucosylating toxins by castanospermine
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Inhibition of the glucosyltransferase activity of clostridial Rho/Ras-glucosylating toxins by castanospermine Inhibition of the glucosyltransferase activity of clostridial Rho/Ras-glucosylating toxins by castanospermine](/preview/png/2050018.png)
چکیده انگلیسی
Castanospermine was identified as an inhibitor of the Rho/Ras-glucosylating Clostridium sordellii lethal toxin and Clostridium difficile toxin B. Microinjection of castanospermine into embryonic bovine lung cells prevented the cytotoxic effects of toxins. The crystal structure of the glucosyltransferase domain of C. sordellii lethal toxin in complex with castanospermine, UDP and a calcium ion was solved at a resolution of 2.3 Å. The inhibitor binds in a conformation that brings its four hydroxyl groups and its N-atom almost exactly in the positions of the four hydroxyls and of the ring oxygen of the glucosyl moiety of UDP–glucose, respectively.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 582, Issue 15, 25 June 2008, Pages 2277–2282
Journal: FEBS Letters - Volume 582, Issue 15, 25 June 2008, Pages 2277–2282
نویسندگان
Thomas Jank, Mathias O.P. Ziegler, Georg E. Schulz, Klaus Aktories,