کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2050027 1074150 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Selenium stimulates pancreatic beta-cell gene expression and enhances islet function
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Selenium stimulates pancreatic beta-cell gene expression and enhances islet function
چکیده انگلیسی

The present study investigated the role of selenium in the regulation of pancreatic beta-cell function. Utilising the mouse beta-cell line Min6, we have shown that selenium specifically upregulates Ipf1 (insulin promoter factor 1) gene expression, activating the −2715 to −1960 section of the Ipf1 gene promoter. Selenium increased both Ipf1 and insulin mRNA levels in Min6 cells and stimulated increases in insulin content and insulin secretion in isolated primary rat islets of Langerhans. These data are the first to implicate selenium in the regulation of specific beta-cell target genes and suggest that selenium potentially promotes an overall improvement in islet function.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 582, Issue 15, 25 June 2008, Pages 2333–2337
نویسندگان
, , , , , , , , ,