کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2050263 1074163 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oncostatin M synergistically inhibits HCV RNA replication in combination with interferon-α
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Oncostatin M synergistically inhibits HCV RNA replication in combination with interferon-α
چکیده انگلیسی

Oncostatin M (OSM), a member of the interleukin-6 family, possesses various functions, including hepatocyte differentiation and suppression of melanoma cell growth. Here, we report anti-hepatitis C virus (HCV) activity of OSM as a new function of this cytokine. OSM possessed marked anti-HCV activity (50% effective concentration: 0.71 ng/ml) in an HCV RNA replication cell culture system. The most striking finding is that OSM exhibited synergistic inhibitory activity on interferon (IFN)-α even at a low concentration with weak anti-HCV activity, such as 25 pg/ml. OSM is a candidate anti-HCV reagent and may improve the current IFN therapy for patients with chronic hepatitis C.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 583, Issue 9, 6 May 2009, Pages 1434–1438
نویسندگان
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