کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2050270 | 1074163 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The three domains of the mitochondrial outer membrane protein Mim1 have discrete functions in assembly of the TOM complex
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
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![عکس صفحه اول مقاله: The three domains of the mitochondrial outer membrane protein Mim1 have discrete functions in assembly of the TOM complex The three domains of the mitochondrial outer membrane protein Mim1 have discrete functions in assembly of the TOM complex](/preview/png/2050270.png)
چکیده انگلیسی
The assembly of mitochondrial outer membrane proteins is an essential process, mediated by the SAM complex and a set of additional protein modules. We show that one of these, Mim1, is anchored in the outer membrane with its N-terminus exposed to the cytosol and its C-terminus in the mitochondrial intermembrane space. Using an in vitro assay to measure the multi-step pathway for assembly of Tom40 into the TOM complex, we find that an “early reaction” mediated by the SAM complex is regulated by the N-terminal domain of Mim1. In addition, a “late reaction” catalysed by the Sam37 subunit of the SAM complex is also influenced by Mim1. Thus, Mim1 participates at multiple stages in the assembly of the TOM complex.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 583, Issue 9, 6 May 2009, Pages 1475–1480
Journal: FEBS Letters - Volume 583, Issue 9, 6 May 2009, Pages 1475–1480
نویسندگان
Franziska Lueder, Trevor Lithgow,