کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2050359 | 1074166 | 2008 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Processing and secretion of the N-terminal domain of α-dystroglycan in cell culture media
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Processing and secretion of the N-terminal domain of α-dystroglycan in cell culture media Processing and secretion of the N-terminal domain of α-dystroglycan in cell culture media](/preview/png/2050359.png)
چکیده انگلیسی
α-Dystroglycan (α-DG) plays a crucial role in maintaining the stability of muscle cell membrane. Although it has been shown that the N-terminal domain of α-DG (α-DG-N) is cleaved by a proprotein convertase, its physiological significance remains unclear. We show here that native α-DG-N is secreted by a wide variety of cultured cells into the culture media. The secreted α-DG-N was both N- and O-glycosylated. Finally, a small amount of α-DG-N was detectable in the normal human serum. These observations indicate that the cleavage of α-DG-N is a widespread event and suggest that the secreted α-DG-N might be transported via systemic circulation in vivo.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 582, Issue 3, 6 February 2008, Pages 439–444
Journal: FEBS Letters - Volume 582, Issue 3, 6 February 2008, Pages 439–444
نویسندگان
Fumiaki Saito, Yuko Saito-Arai, Ayami Nakamura, Teruo Shimizu, Kiichiro Matsumura,