کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2050485 | 1074171 | 2007 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Direct neurite-osteoblastic cell communication, as demonstrated by use of an in vitro co-culture system
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Direct neurite-osteoblastic cell communication, as demonstrated by use of an in vitro co-culture system Direct neurite-osteoblastic cell communication, as demonstrated by use of an in vitro co-culture system](/preview/png/2050485.png)
چکیده انگلیسی
Using an in vitro co-culture approach comprising cultured murine superior cervical ganglia and MC3T3-E1 osteoblast-like cells, we found that the addition of scorpion venom (SV) elicited neurite activation via intracellular Ca2+ mobilization and, after a lag period, osteoblastic Ca2+ mobilization. SV did not have any direct effect on the osteoblastic cells in the absence of neurites. The addition of an α1-adrenergic receptor (AR) antagonist, prazosin, dose-dependently prevented the osteoblastic activation that resulted as a consequence of neural activation by SV. These results demonstrate that osteoblastic activation occurred as a direct response to neuronal activation, which activation was mediated by α1-ARs in the osteoblastic cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 30, 22 December 2007, Pages 5917–5922
Journal: FEBS Letters - Volume 581, Issue 30, 22 December 2007, Pages 5917–5922
نویسندگان
Koji Obata, Tadahide Furuno, Mamoru Nakanishi, Akifumi Togari,