کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2050514 | 1074172 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
ZIC1 gene expression is controlled by DNA and histone methylation in mesenchymal proliferations
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: ZIC1 gene expression is controlled by DNA and histone methylation in mesenchymal proliferations ZIC1 gene expression is controlled by DNA and histone methylation in mesenchymal proliferations](/preview/png/2050514.png)
چکیده انگلیسی
RNA and protein analysis revealed the consistent upregulation of the neural transcription factors ZIC1 and ZIC4 in desmoid tumors and other fibroproliferative disorders. The 5′ flanking region of the ZIC1 promoter was unmethylated in desmoid tumor fibroblasts, while a hypermethylated ZIC1 promoter was found in human and mouse cell lines not expressing the gene. In addition, expressing cells showed a H3K4me2 at the ZIC1 promoter, whereas non-expressing cells showed higher levels of H3K9me2 in the same region. To our knowledge, this is the first report describing ZIC1 expression in mesenchymal proliferations and a role for DNA methylation in the control of ZIC1 expression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 26, 30 October 2007, Pages 5122–5126
Journal: FEBS Letters - Volume 581, Issue 26, 30 October 2007, Pages 5122–5126
نویسندگان
Rasoul Pourebrahim, Kim Van Dam, Marijke Bauters, Ivo De Wever, Raf Sciot, Jean-Jacques Cassiman, Sabine Tejpar,