کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2050573 | 1074174 | 2007 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Hsp90-mediated inhibition of FKBP38 regulates apoptosis in neuroblastoma cells Hsp90-mediated inhibition of FKBP38 regulates apoptosis in neuroblastoma cells](/preview/png/2050573.png)
The FK506-binding protein 38 (FKBP38) is a pro-apoptotic regulator of Bcl-2 in neuroblastoma cells. Hsp90 inhibits the pro-apoptotic FKBP38/CaM/Ca2+ complex and thus prevents interactions between FKBP38 and Bcl-2. Here we show that Hsp90 increases cell survival rates of neuroblastoma cells after apoptosis induction. Depletion of FKBP38 by short interference RNA significantly decreased the anti-apoptotic effect of Hsp90 expression. In addition, the influence of high cellular Hsp90 levels was only observed in post-stimulation apoptosis that is sensitive to selective FKBP38 active site inhibition. Similar anti-apoptotic effects in neuroblastoma cells were observed after stimulation of endogenous Hsp90 expression. Hence, the inhibition of FKBP38 by Hsp90 participates in programmed cell death control of neuroblastoma cells.
Journal: FEBS Letters - Volume 581, Issue 29, 11 December 2007, Pages 5709–5714