کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2050635 1074176 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inhibitory role of RhoA on senescence-like growth arrest by a mechanism involving modulation of phosphatase activity
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Inhibitory role of RhoA on senescence-like growth arrest by a mechanism involving modulation of phosphatase activity
چکیده انگلیسی

Recently, negative effects of phosphatase in tumorigenesis and metastasis have been suggested in various tumor types. In this study, we showed that RhoA activation modulated phosphatase during senescence-like arrest in human prostate cancer cells. Under senescence-inducing condition, decreased Erk phosphorylation was detected in caRhoA-transfected cells and inactivation of Erk, but not p38, prevented doxorubicin-induced cell senescence. Cells were induced to senescence by inhibition of phosphatase activity (VHR, MKP3, or PP2A) without additional cellular stress. Of interest, caRhoA prevented doxorubicin-induced decrease of phosphatase. Thus, we postulate that RhoA signaling may protect cells against cellular senescence by maintaining phosphatase activity and Erk dephosphorylation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 20, 7 August 2007, Pages 3800–3804
نویسندگان
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