کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2050686 | 1074177 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Induction of podoplanin by transforming growth factor-β in human fibrosarcoma
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Induction of podoplanin by transforming growth factor-β in human fibrosarcoma Induction of podoplanin by transforming growth factor-β in human fibrosarcoma](/preview/png/2050686.png)
چکیده انگلیسی
Podoplanin/aggrus is increased in tumors and its expression was associated with tumor malignancy. Podoplanin on cancer cells serves as a platelet-aggregating factor, which is associated with the metastatic potential. However, regulators of podoplanin remain to be determined. Transforming growth factor-β (TGF-β) regulates many physiological events, including tumorigenesis. Here, we found that TGF-β induced podoplanin in human fibrosarcoma HT1080 cells and enhanced the platelet-aggregating-ability of HT1080. TGF-β type I receptor inhibitor (SB431542) and short hairpin RNAs for Smad4 inhibited the podoplanin induction by TGF-β. These results suggest that TGF-β is a physiological regulator of podoplanin in tumor cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 582, Issue 2, 23 January 2008, Pages 341–345
Journal: FEBS Letters - Volume 582, Issue 2, 23 January 2008, Pages 341–345
نویسندگان
Hiroyuki Suzuki, Yukinari Kato, Mika Kato Kaneko, Yukari Okita, Hisashi Narimatsu, Mitsuyasu Kato,