کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2050771 1074181 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The C-terminus of the yeast Lsm4p is required for the association to P-bodies
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
The C-terminus of the yeast Lsm4p is required for the association to P-bodies
چکیده انگلیسی

We previously reported that Saccharomyces cerevisiae mutants in mRNA decapping and mutants expressing a truncated form of the KlLSM4 gene, showed premature senescence and apoptotic phenotypes.Here, we show that this truncated protein is dispersed in the cytoplasm and does not assemble to P-bodies. As reported in decapping mutants, we observed an increase in the number of P-bodies suggesting that the truncation of the protein impairs this process. The number of P-bodies also increases after oxidative stress and is not dependent on the meta-caspase gene YCA1, placing this phenomenon upstream to the onset of apoptosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 25, 16 October 2007, Pages 4836–4840
نویسندگان
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