کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2050942 | 1074186 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
IFNγ enhances IL-23 production during Francisella infection of human monocytes
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We previously demonstrated that monocytes produce IL-23 during Francisella infection, and that IL-23 induces IFNγ from NK cells. Here, we demonstrate that IFNγ-priming of monocytes enhances IL-23 production during Francisella infection. This effect was seen on the IL12/23 p40 subunit. Induction of IL-12/23 p40 is reported to be enhanced by IRF-1 and IRF-8. Consistently, microarray analysis of IFNγ-treated monocytes revealed a significant induction of the IRFs. Interestingly, IFNγ-primed monocytes produced IL-12 p70, a more potent inducer of IFNγ than IL-23. We propose that there exists an amplification loop between monocyte IL-23 and NK/T cell IFNγ that leads to IL-12 p70 production.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 582, Issue 7, 2 April 2008, Pages 1044–1048
Journal: FEBS Letters - Volume 582, Issue 7, 2 April 2008, Pages 1044–1048
نویسندگان
Jonathan P. Butchar, Kishore V.L. Parsa, Clay B. Marsh, Susheela Tridandapani,