کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2051272 | 1074196 | 2007 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Transformation of the proteasome with age-related macular degeneration
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Transformation of the proteasome with age-related macular degeneration Transformation of the proteasome with age-related macular degeneration](/preview/png/2051272.png)
چکیده انگلیسی
The proteasome mediates pathways associated with oxidative stress and inflammation, two pathogenic events correlated with age-related macular degeneration (AMD). In human donor eyes corresponding to four stages of AMD, we found the proteasomal chymotrypsin-like activity increased in neurosensory retina with disease progression. Increased activity correlated with a dramatic increase in the inducible subunits of the immunoproteasome, which was not due to an increase in CD45 positive immune cells in the retina. The novel observation of proteasome transformation may reflect retinal response to local inflammation or oxidative stress with AMD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 5, 6 March 2007, Pages 885–890
Journal: FEBS Letters - Volume 581, Issue 5, 6 March 2007, Pages 885–890
نویسندگان
Cheryl M. Ethen, Stacy A. Hussong, Cavan Reilly, Xiao Feng, Timothy W. Olsen, Deborah A. Ferrington,