کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2051294 1074196 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Slit3 regulates cell motility through Rac/Cdc42 activation in lipopolysaccharide-stimulated macrophages
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Slit3 regulates cell motility through Rac/Cdc42 activation in lipopolysaccharide-stimulated macrophages
چکیده انگلیسی

Three slit genes, slit1 to slit3, have been cloned to date. Slit1 and slit2 act as chemorepellent factors for axon guidance. Slit3 is involved in the formation of the diaphragm and kidney during embryogenesis. However, its molecular function remains unclear. We found that slit3 expression was induced by lipopolysaccharide (LPS)-stimulation in macrophages and that it was localized in the mitochondria and along the plasma membrane. Silencing of slit3 expression by RNA interference reduced cell motility and Rac/Cdc42 activation. These results suggest that slit3 functions as an intracellular signaling molecule for cell motility as part of the LPS-induced signaling cascade.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 5, 6 March 2007, Pages 1022–1026
نویسندگان
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