کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2051374 | 1074198 | 2007 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Appropriate expression of imprinted genes on mouse chromosome 12 extends development of bi-maternal embryos to term
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Recently, we reported that the restored regulation of imprinted gene expression from two regions – H19 differentially methylated region (H19-DMR) and intergenic germline-derived DMR (IG-DMR) – is sufficient for accomplishing full-term development in mice. In the present study, we determined the developmental ability of the bi-maternal embryos (BMEs) containing the non-growing oocyte genome with the IG-DMR deletion (ngΔch12) and fully-grown (fg) oocyte genome. Foetuses derived from ngΔch12/fg BMEs were alive at E19.5 but could not survive further. Comparison with BMEs derived from Igf2+/− ng/fg genomes suggests that bi-allelic H19 expression might be involved in foetal development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 27, 13 November 2007, Pages 5178–5184
Journal: FEBS Letters - Volume 581, Issue 27, 13 November 2007, Pages 5178–5184
نویسندگان
Manabu Kawahara, Qiong Wu, Anne C. Ferguson-Smith, Tomohiro Kono,