کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2051491 1074202 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
GSH-dependent regulation of Fas-mediated caspase-8 activation by acrolein
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
GSH-dependent regulation of Fas-mediated caspase-8 activation by acrolein
چکیده انگلیسی

Activation of the cysteine protease caspase-8 by the death receptor Fas (CD95/APO-1) in B lymphoblastoid SKW6.4 cells or Jurkat T cells is associated with GSH depletion. Conversely, GSH depletion by the aldehyde acrolein (3–30 μM) was associated with inhibition of Fas-induced caspase-8 activation, although GSH depletion by buthionine sulfoximine (BSO) did not affect caspase-8 activation. In contrast to BSO, acrolein caused a loss of caspase-8 cysteine content in association with direct alkylation of caspase-8. Our findings indicate that inhibition of caspase-8 by thiol-reactive agents such as acrolein is not due to GSH depletion but caused by direct protein thiol modifications.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 3, 6 February 2007, Pages 361–367
نویسندگان
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