کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2051510 1074202 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
UCP2 is a mitochondrial transporter with an unusual very short half-life
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
UCP2 is a mitochondrial transporter with an unusual very short half-life
چکیده انگلیسی

This study focused on the stability of UCP2 (uncoupling protein 2), a mitochondrial carrier located in the inner membrane of mitochondrion. UCP2 is very unstable, with a half-life close to 30 min, compared to 30 h for its homologue UCP1, a difference that may highlight different physiological functions. Heat production by UCP1 in brown adipocytes is generally a long and adaptive phenomenon, whereas control of mitochondrial ROS by UCP2 needs more subtle regulation. We show that a mutation in UCP2 shown to modify its activity, actually decreases its stability.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 3, 6 February 2007, Pages 479–482
نویسندگان
, , , , , , ,