کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2051598 | 1074205 | 2007 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: hnRNP-U enhances the expression of specific genes by stabilizing mRNA hnRNP-U enhances the expression of specific genes by stabilizing mRNA](/preview/png/2051598.png)
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are thought to be involved in pre-mRNA processing. hnRNP-U, also termed scaffold attachment factor A (SAF-A), binds to pre-mRNA and nuclear matrix/scaffold attachment region DNA elements. However, its role in the regulation of gene expression is as yet poorly understood. In the present study, we show that hnRNP-U specifically enhances the expression of tumor necrosis factor α mRNA by increasing its stability, possibly through binding to the 3′ untranslated region. We also show that hnRNP-U enhances the expression of several other genes as well, including GADD45A, HEXIM1, HOXA2, IER3, NHLH2, and ZFY, by binding to and stabilizing these mRNAs. These results suggest that hnRNP-U enhances the expression of specific genes by regulating mRNA stability.
Journal: FEBS Letters - Volume 581, Issue 1, 9 January 2007, Pages 1–7