کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2051777 1074210 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Current challenges in quantitative modeling of epidermal growth factor signaling
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Current challenges in quantitative modeling of epidermal growth factor signaling
چکیده انگلیسی

Over the last decade, epidermal growth factor (EGF) signaling has been used repeatedly as a testbed for pioneering computational systems biology. Recent breakthroughs in our molecular understanding of EGF signaling pose new challenges for mathematical modeling strategies. Three key areas emerge as particularly relevant: the pervasive importance of compartmentalization and endosomal trafficking; the complexity of signalosome complexes; and the regulatory influence of diffusion and spatiality. Each one of them demands a drastic change in current computational approaches. We discuss recent developments in the field that address these emerging aspects in a new generation of more realistic – and potential more useful – models of EGF signaling.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 579, Issue 28, 21 November 2005, Pages 6289–6294
نویسندگان
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