کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2051802 | 1074210 | 2005 | 8 صفحه PDF | دانلود رایگان |
Platelet-activating factor (PAF) augments angiogenesis by promoting the synthesis of a variety of angiogenic factors, via the nuclear factor (NF)-κB activation. Recently, we reported that PAF upregulates MMP-9 expression in a NF-κB-dependent manner. In this study, we investigated the signaling pathway involved in PAF-induced MMP-9 expression in ECV304 cells. Our current data indicate that the Ca2+- or phosphatidylinositol 3-kinase (PI3K)-dependent signaling pathway is necessary for PAF-induced MMP-9 expression. Furthermore, PAF-induced NF-κB activation was blocked by selective inhibitors of Ca2+, PI3K, or extracellular signal-regulated kinase (ERK). Our results suggest that PAF-induced MMP-9 expression, in a NF-κB-dependent manner, is regulated by Ca2+, PI3K and ERK signaling pathways.
Journal: FEBS Letters - Volume 579, Issue 28, 21 November 2005, Pages 6451–6458