Keywords: فسفاتیدیل اینوزیتول -3; FNAB, fine-needle aspiration biopsy; MAPK, mitogen-activated protein kinase; PTC, papillary thyroid carcinoma; FTC, follicular thyroid carcinoma; FISH, fluorescence in situ hybridization; PI3K, phosphatidylinositol 3-kinase; FVPTC, follicular variant of p
مقالات ISI فسفاتیدیل اینوزیتول -3 (ترجمه نشده)
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Keywords: فسفاتیدیل اینوزیتول -3; IRS-1, Insulin receptor substrate-1; PI3K, phosphatidylinositol 3-kinase; KI, knock-in; BCA, bicinchoninic acid; BSA, bovine serum albumin; HRP, horseradish peroxidase; ELISA, enzyme-linked immunosorbent assayLiver insulin signaling; ApoE; Akt signaling;
Keywords: فسفاتیدیل اینوزیتول -3; H2DCF-DA, 2′,7′-dichlorodihydrofluorescein diacetate; DHE, dihydroethidium; HSPG, heparan sulfate proteoglycans; NAC, N-acetyl-L-cysteine; PI3K, phosphatidylinositol 3-kinase; PEI, polyethylenimine; rAAV, recombinant adeno-associated virus; ROS, reactive
Keywords: فسفاتیدیل اینوزیتول -3; IGF-1, insulin-like growth factor-1; DM, diabetes mellitus; SMCs, smooth muscle cells; GH, growth hormone; IGF-R, IGF receptors; IGFBPs, IGF-binding proteins; PI3K, phosphatidylinositol 3-kinase; MAPK, mitogen-activated protein kinase; H–E, hematoxylin–eo
Keywords: فسفاتیدیل اینوزیتول -3; MIF, Human macrophage migration inhibitory factor; Mif, mouse macrophage migration inhibitory factor; mrMif, mouse recombinant macrophage migration inhibitory factor; PI3K, phosphatidylinositol 3-Kinase; Mdm2, transformed mouse 3T3 cell double-minute 2; A
MicroRNA-29a contributes to drug-resistance of breast cancer cells to adriamycin through PTEN/AKT/GSK3β signaling pathway
Keywords: فسفاتیدیل اینوزیتول -3; ADR, adriamycin; miRNAs, microRNAs; IGF-1R, insulin-like growth factor-1 receptor; GSK3β, Glycogen Synthase Kinase 3β; PTEN, phosphatase and tensin homolog deleted on chromosome 10; PI3K, phosphatidylinositol 3-kinase; IC50, the inhibitory concentration t
Human cathelicidin LL-37 inhibits platelet aggregation and thrombosis via Src/PI3K/Akt signaling
Keywords: فسفاتیدیل اینوزیتول -3; LL-37; Antiplatelet; Antithrombosis; Src/PI3K/Akt signalingAMP, antimicrobial peptide; ADP, adenosine diphosphate; TxA2, thromboxane A2; GPIIb/IIIa, glycoprotein IIb–IIIa; MAPK, mitogen activated protein kinase; PI3K, phosphatidylinositol 3-kinase; SD, Sp
The effect of Liuwei Dihuang decoction on PI3K/Akt signaling pathway in liver of type 2 diabetes mellitus (T2DM) rats with insulin resistance
Keywords: فسفاتیدیل اینوزیتول -3; IRS2, insulin receptor substrate 2; PI3K, phosphatidylinositol 3-kinase; Akt, protein kinase B; T2DM, type 2 diabetes mellitusMorroniside(C17H26O11,402.38); Sweroside(C16H22O9,358.34); Paeonoside(C23H28O11, 480.47); Loganin(:C17H26O10,390.38)Type 2 diabet
Ca2+ effects on glucose transport and fatty acid oxidation in L6 skeletal muscle cell cultures
Keywords: فسفاتیدیل اینوزیتول -3; CaMKK, Calmodulin kinase; PI3K, Phosphatidylinositol 3-kinase; KHB, Krebs Henseleit bicarbonate; CAT I, Carnitine acyl transferaseGlucose transport; Fatty acid oxidation; AMP kinase; Skeletal muscle; L6 cells
Sphingosine-1-phosphate/S1PR2-mediated signaling triggers Smad1/5/8 phosphorylation and thereby induces Runx2 expression in osteoblasts
Keywords: فسفاتیدیل اینوزیتول -3; ALP, alkaline phosphatase; BMP, bone morphogenetic protein; ERK, extracellular signal regulated protein kinase; GSK-3β, glycogen synthase kinase 3β; I-Smad, inhibitory Smad; PI3K, phosphatidylinositol 3-kinase; ROCK, Rho kinase; ROI, region of interest; R
Autophagy regulates intracerebral hemorrhage induced neural damage via apoptosis and NF-κB pathway
Keywords: فسفاتیدیل اینوزیتول -3; Intracerebral hemorrhage; Neuron; Autophagy; Apoptosis; InflammationICH, intracerebral hemorrhage; 3-MA, 3-Methyladenine; RAP, rapamycin; LC3, Microtubule-associated protein 1 light chain 3; BBB, blood–brain barrier; PI3K, phosphatidylinositol 3-kinase; A
Discontinuing MEK inhibitors in tumor cells with an acquired resistance increases migration and invasion
Keywords: فسفاتیدیل اینوزیتول -3; DMSO, dimethyl sulfoxide; mTOR, mammalian target of rapamycin; PI3K, phosphatidylinositol 3-kinase; EMT, epithelial–mesenchymal transition; EMT-TF, epithelial–mesenchymal transition inducing transcription factor; ERK1/2, extracellular-signal regulated kin
Fine particulate matter leads to reproductive impairment in male rats by overexpressing phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway
Keywords: فسفاتیدیل اینوزیتول -3; PM, particulate matter; ROS, reactive oxygen species; NS, normal saline; Cx43, connexin 43; SOD, superoxide dismutase; BTB, blood–testis barrier; PI3K, phosphatidylinositol 3-kinase; p-Akt, phosphorylated protein kinase B; SD, Sprague-Dawley; PBST, phosph
Prostaglandin E2-stimulated prostanoid EP4 receptors induce prolonged de novo prostaglandin E2 synthesis through biphasic phosphorylation of extracellular signal-regulated kinases mediated by activation of protein kinase A in HCA-7 human colon cancer cell
Keywords: فسفاتیدیل اینوزیتول -3; cAMP, cyclic AMP; EP receptor, E-type prostanoid receptor; PI3K, phosphatidylinositol 3-kinase; ERKs, extracellular signal-regulated kinases; PKA, protein kinase A; ICL, intracellular loop; PGE2, prostaglandin E2; COX-2, cyclooxygenase-2; EGF, epidermal g
RhoC Mediates Epidermal Growth Factor-Stimulated Migration and Invasion in Head and Neck Squamous Cell Carcinoma
Keywords: فسفاتیدیل اینوزیتول -3; EGFR, epidermal growth factor receptor; EGF, epidermal growth factor; HNSCC, head a neck squamous cell carcinoma; PI3K, phosphatidylinositol 3-kinase; STAT3, signal transducer and activator of transcription 3; EMT, epithelial mesenchymal transition; GSK3β
Myricitrin attenuates endothelial cell apoptosis to prevent atherosclerosis: An insight into PI3K/Akt activation and STAT3 signaling pathways
Keywords: فسفاتیدیل اینوزیتول -3; Ox-LDL, oxidized low-density lipoprotein; ROS, reactive oxygen species; ApoE −/−, apolipoprotein E-deficient; LOX-1, lectin-like ox-LDL receptor-1; HUVECs, human umbilical vein endothelial cells; PI3K, phosphatidylinositol 3-kinase; Akt, protein kinase B;
The TLR3, PI3K, survin, FasL, and Fas genes as major risk factors of occurrence and development of cervical cancer disease
Keywords: فسفاتیدیل اینوزیتول -3; TLR, Toll-like receptor; DCs, dendritic cells; PI3K, phosphatidylinositol 3-kinase; PIP3, phosphatidylinositol 3,4,5-triphosphateTLR3/PI3K signals; Cervical cancer; Mice; Survivin
Obligatory roles of filamin A in E-cadherin-mediated cell–cell adhesion in epidermal keratinocytes
Keywords: فسفاتیدیل اینوزیتول -3; Cao2+, extracellular Ca2+; CaR, calcium-sensing receptor; AJ, adherens junction; PI3K, phosphatidylinositol 3-kinase; siRNA, small interfering RNA; GEF, guanine nucleotide exchange factorFilamin; E-cadherin; Calcium-sensing receptor; Rho A; Trio; Keratino
The specifically enhanced cellular immune responses in Pacific oyster (Crassostrea gigas) against secondary challenge with Vibrio splendidus
Keywords: فسفاتیدیل اینوزیتول -3; PI3K, phosphatidylinositol 3-kinase; MAPKK, mitogen-activated protein kinase kinase; PKC, protein kinase C; NADPH, nicotinamide adenine dinucleotide phosphate; BMP, bone morphogenetic protein; EF, elongation factorCrassostrea gigas; Immune priming; Phagoc
17β-Estradiol inhibition of IL-6–Src and Cas and paxillin pathway suppresses human mesenchymal stem cells–mediated gastric cancer cell motility
Keywords: فسفاتیدیل اینوزیتول -3; E2, 17β-estradiol; ERK, extracellular signal regulated kinase; HBMMSCs, human bone marrow mesenchymal stem cells; IL-6, interleukin 6; JNK, c-Jun N-terminal kinase; PI3K, phosphatidylinositol 3-kinase; p38 MAPK, p38 mitogen-activated protein kinase; Akt,
Design and synthesis of novel 2-methyl-4,5-substitutedbenzo[f]-3,3a,4,5-tetrahydro-pyrazolo[1,5-d][1,4]oxazepin-8(7H)-one derivatives as telomerase inhibitors
Keywords: فسفاتیدیل اینوزیتول -3; PI3K, phosphatidylinositol 3-kinase; AKT, serine/threonine Kinase; GPCR, G-protein coupled receptor; hTERT, human telomerase reverse transcriptase subunit; BIBR1532, 2-[E)-3-naphtalen-2-yl-but-2-enylylamino]-benzoic acid; MGC-803, The human gastric carcin
Histone deacetylase inhibitor AR42 regulates telomerase activity in human glioma cells via an Akt-dependent mechanism
Keywords: فسفاتیدیل اینوزیتول -3; TRAP, telomeric repeat amplification protocol; HDAC, histone deacetylase; PI3K, phosphatidylinositol 3-kinase; RT-PCR, reverse transcriptase-polymerase chain reactionTelomerase reverse transcriptase; Histone deacetylase inhibitor; Glioma; PI3K/Akt pathway
Mutations in K-Ras linked to levels of osteoprotegerin and sensitivity to TRAIL-induced cell death in pancreatic ductal adenocarcinoma cells
Keywords: فسفاتیدیل اینوزیتول -3; OPG, osteoprotegerin (TNFRSF11B, tumor necrosis factor superfamily 11 B); TRAIL, TNF-related apoptosis-inducing ligand; PDAC, pancreatic ductal adenocarcinoma; MAPK, mitogen-activated protein kinase; PI3K, phosphatidylinositol 3-kinase; EGF, epidermal gro
Neurotoxicity of developmental hypothyroxinemia and hypothyroidism in rats: Impairments of long-term potentiation are mediated by phosphatidylinositol 3-kinase signaling pathway
Keywords: فسفاتیدیل اینوزیتول -3; LTP, long-term potentiation; PI3K, phosphatidylinositol 3-kinase; MMZ, methimazole; TH, thyroid hormones; CNS, central nervous system; ID, iodine deficiency; FT4, free thyroxine; FT3, free triiodothyronine; TSH, thyroid stimulating hormone; mTOR, Mammalia
New insights into the role of sphingosine 1-phosphate and lysophosphatidic acid in the regulation of skeletal muscle cell biology
Keywords: فسفاتیدیل اینوزیتول -3; CTGF, connective tissue growth factor; DMS, dimethylsphingosine; ERK, extracellular signal-regulated kinase; IGF-1, insulin like growth factor-1; LPA, lysophosphatidic acid; PDGF, platelet-derived growth factor; PI3K, phosphatidylinositol 3-kinase; alphaS
Sphingosine-1-phosphate promotes the nuclear translocation of β-catenin and thereby induces osteoprotegerin gene expression in osteoblast-like cell lines
Keywords: فسفاتیدیل اینوزیتول -3; ALP, alkaline phosphatase; BMP, bone morphogenetic protein; GPCR, G-protein-coupled receptors; GSK-3β, glycogen synthase kinase 3β; LEF, lymphoid enhancer-binding factor; OPG, osteoprotegerin; PI3K, phosphatidylinositol 3-kinase; RANKL, receptor activator
Insulin resistance: An adaptive mechanism becomes maladaptive in the current environment — An evolutionary perspective
Keywords: فسفاتیدیل اینوزیتول -3; MS, metabolic syndrome; DM2, type 2 diabetes mellitus; CVD, cardiovascular disease; TGs, triglycerides; IRS, insulin receptor substrates; PI3K, phosphatidylinositol 3-kinase; Akt/PKB, Protein kinase B; MAPK, mitogen activated protein kinase; JNK, c-Jun am
Enhanced apoptotic effects by downregulating Mcl-1: Evidence for the improvement of photodynamic therapy with Celecoxib
Keywords: فسفاتیدیل اینوزیتول -3; Mcl-1, myeloid cell leukemia 1; PDT, photodynamic therapy; MEK, mitogen-activated protein kinase; ERK, extracellular signal-regulated kinase; PI3K, phosphatidylinositol 3-kinase; VEGF, vascular epidermal growth factor; GSK, glycogen synthase kinase; COX-2
LY294002 inhibits TLR3/4-mediated IFN-β production via inhibition of IRF3 activation with a PI3K-independent mechanism
Keywords: فسفاتیدیل اینوزیتول -3; PI3K, phosphatidylinositol 3-kinase; TLR, toll-like receptor; IRF3, interferon regulatory factor 3; IFN-β, interferon βLY294002; Toll-like receptor; Phosphatidylinositol 3-kinase; IRF3; IFN-β
PI3K/AKT and ERK regulate retinoic acid-induced neuroblastoma cellular differentiation
Keywords: فسفاتیدیل اینوزیتول -3; PI3K, phosphatidylinositol 3-kinase; ERK, extracellular-signal-regulated kinase; RA, retinoic acid; RARs, all-trans-RA (ATRA) receptor; RXRs, retinoid X (9-cis-RA) receptorPI3K; ERK; Retinoic acid; Differentiation; Neuroblastoma
Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs
Keywords: فسفاتیدیل اینوزیتول -3; IRS, insulin receptor substrate; IGF, insulin-like growth factor; PI3K, phosphatidylinositol 3-kinase; SH2, src homology region 2; USP7, ubiquitin specific protease 7; Grb2, growth factor receptor-bound protein 2; Erk, extracellular signal-regulated kinas
PI3-kinase and mTOR inhibitors differently modulate the function of the ABCG2 multidrug transporter
Keywords: فسفاتیدیل اینوزیتول -3; ABC, ATP-binding cassette; PI3K, phosphatidylinositol 3-kinase; mTOR, mammalian target of rapamycin; MDR, multidrug resistanceABCG2; PI3-kinase/Akt/mTOR signaling; LY294002; Wortmannin; Rapamycin
p62/SQSTM1/A170: Physiology and pathology
Keywords: فسفاتیدیل اینوزیتول -3; aPKC, atypical protein kinase C; ER, endoplasmic reticulum; LIR, LC3-interacting region; mTORC1, mammalian target of rapamycin complex 1; PB1, Phox and Bem1p; PDB, Paget disease of bone; PE, phosphatidylethanolamine; PI3K, phosphatidylinositol 3-kinase; P
Gli inhibitor GANT61 causes apoptosis in myeloid leukemia cells and acts in synergy with rapamycin
Keywords: فسفاتیدیل اینوزیتول -3; Hh, hedgehog; smo, smoothened; rShh, recombinant sonic hedgehog; PI3K, phosphatidylinositol 3-kinase; mTOR, mammalian target of rapamycin; GSK3β, Glycogen synthase kinase 3β; AML, acute myeloid leukemiaHedgehog/Gli; mTOR; AML; GANT61; Rapamycin; Apoptosis
Prognostic markers in renal cell carcinoma: A focus on the ‘mammalian target of rapamycin’ pathway
Keywords: فسفاتیدیل اینوزیتول -3; mTOR, mammalian target of rapamycin; LDH, lactate dehydrogenase; VEGF, vascular endothelial growth factor; VHL, von Hippel-Lindau; HIF, hypoxia inducible factor; PI3k, phosphatidylinositol 3-kinase; S6K1, S6 kinase 1; 4E-BP1, eukaryotic initiation factor-
Canine tumors: a spontaneous animal model of human carcinogenesis
Keywords: فسفاتیدیل اینوزیتول -3; AKT1, akt-murine thymoma viral oncogene homolog 1; ER, estrogen receptor; EGFR, epidermal growth factor receptor; ERA, estrogen receptor-alpha; MAPK, mitogen-activated protein kinase; PI3K, phosphatidylinositol 3-kinase; PIK3CA, phosphoinositide-3-kinase,
New Understandings on Folliculogenesis/Oogenesis Regulation in Mouse as Revealed by Conditional Knockout
Keywords: فسفاتیدیل اینوزیتول -3; Conditional knockout; Folliculogenesis; Oogenesis; MouseGC, granulosa cell; PN, postnatal; PI3K, phosphatidylinositol 3-kinase; PIP2, phosphatidylinositol (4,5)-bisphosphate; PIP3, phosphatidylinositol (3,4,5)-trisphosphate; PTEN, phosphatase and tensin h
Reduction of metastasis, cell invasion, and adhesion in mouse osteosarcoma by YM529/ONO-5920-induced blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathway
Keywords: فسفاتیدیل اینوزیتول -3; MMPs, matrix metalloproteinases; ERK1/2, extracellular signal-regulated kinase 1/2; MEK1/2, mitogen-activated protein kinase kinase 1/2; PI3K, phosphatidylinositol 3-kinase; ECM, extracellular matrix; BPs, BisphosphonatesBisphosphonate; Osteosarcoma; Ras;
The Phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 modulates cytokine expression in macrophages via p50 nuclear factor kappa B inhibition, in a PI3K-independent mechanism
Keywords: فسفاتیدیل اینوزیتول -3; LPS, lipopolysaccharide; TNFα, tumor necrosis factor alpha; IL-10, interleukin-10; PI3K, Phosphatidylinositol 3-kinase; LY2, LY294002; LY3, LY303511; NFκB, nuclear factor κB; Wort, wortmannin; PVDF, polyvinylidene fluoride; wed, wedelolactone; EMSA, elect
HMGB-1 induces cell motility and α5β1 integrin expression in human chondrosarcoma cells
Keywords: فسفاتیدیل اینوزیتول -3; HMGB-1, high mobility group box chromosomal protein 1; RAGE, receptor for advanced glycation end products; PI3K, phosphatidylinositol 3-kinase; ECM, extracellular matrix; siRNA, small interfering RNA; qPCR, quantitative real time PCRHMGB-1; Chondrosarcoma
Down-regulation of interleukin-2 production by CD4+ T cells expressing TIM-3 through suppression of NFAT dephosphorylation and AP-1 transcription
Keywords: فسفاتیدیل اینوزیتول -3; NFAT, nuclear factor of activated T cells; PD-1, programmed death-1; PI3K, phosphatidylinositol 3-kinase; PMA, phorbol myristate acetate; SD, standard deviation; TIM-3, T cell immunoglobulin mucin domain containing molecule-3AP-1; CD4+ T cells; IL-2; NFAT
PKCη is a negative regulator of AKT inhibiting the IGF-I induced proliferation
Keywords: فسفاتیدیل اینوزیتول -3; PKB, protein kinase B; PKC, protein kinase C; PMA, phorbol 12-myristate 13-acetate; IGF, Insulin-like growth factor; PDGF, platelet derived growth factor; PDK-1, Phosphoinositide-dependent kinase-1; PI3K, phosphatidylinositol 3-kinase; shRNA, short hairpi
IL-6 inhibits IFN-γ induced autophagy in Mycobacterium tuberculosis H37Rv infected macrophages
Keywords: فسفاتیدیل اینوزیتول -3; Autophagy; IFN-γ; IL-6; MycobacteriamTOR, mammalian target of rapamycin; PI3K, phosphatidylinositol 3-kinase; LC3, microtubule-associated protein 1 light chain 3
Effects of antipsychotic drugs on BDNF, GSK-3β, and β-catenin expression in rats subjected to immobilization stress
Keywords: فسفاتیدیل اینوزیتول -3; BDNF, brain-derived neurotrophic factor; CRE, cAMP response element; CREB, CRE binding protein; GSK-3β, glycogen synthase kinase-3β; PKA, protein kinase A; PI3K, phosphatidylinositol 3-kinase; TCF/LEF, T-cell-specific transcription factor/lymphoid enhance
Chronic treatment with epoxyeicosatrienoic acids modulates insulin signaling and prevents insulin resistance in hepatocytes
Keywords: فسفاتیدیل اینوزیتول -3; EETs, epoxyeicosatrienoic acids; PI3K, phosphatidylinositol 3-kinase; JNK, c-Jun N-terminal kinase; IRS-1, insulin receptor substrate-1; sEH, soluble epoxide hydrolaseInsulin resistance; Epoxyeicosatrienoic acids; Insulin signal; AKT; PI3K; JNK
Growth factor signaling enhances aromatase activity of breast cancer cells via post-transcriptional mechanisms
Keywords: فسفاتیدیل اینوزیتول -3; PI3K, phosphatidylinositol 3-kinase; Akt, protein kinase B; MAPK, mitogen activated protein kinase; COX2, cyclooxygenase 2; PGE2, prostaglandin E2; EP, PGE2 receptor; ER, estrogen receptor; EGF, epidermal growth factor; TGFα, transforming growth factor α;
In vitro and in vivo effects of a cyclooxygenase-2 inhibitor nimesulide analog JCC76 in aromatase inhibitors-insensitive breast cancer cells
Keywords: فسفاتیدیل اینوزیتول -3; AI, aromatase inhibitor; PI3K, phosphatidylinositol 3-kinase; PDK, phosphoinositide-dependent kinase; AKt, protein kinase B; MAPK, mitogen activated protein kinase; COX2, cyclooxygenase 2; NSAIDs, Non-steroidal anti-inflammatory drugs; ER, estrogen recept
Aldose reductase in keratinocytes attenuates cellular apoptosis and senescence induced by UV radiation
Keywords: فسفاتیدیل اینوزیتول -3; AR, aldose reductase; UV, ultraviolet; ROS, reactive oxygen species; MAPK, mitogen-activated protein kinase; JNK, c-Jun N-terminal kinase; PI3K, phosphatidylinositol 3-kinase; ERK, extracellular signal-regulated kinase; EBPC, ethyl 1-benzyl-3-hydroxy-2-(5
SNARE-mediated membrane traffic is required for focal adhesion kinase signaling and Src-regulated focal adhesion turnover
Keywords: فسفاتیدیل اینوزیتول -3; CHO, Chinese hamster ovary; ECM, extracellular matrix; FN, fibronectin; FA, focal adhesions; FAK, focal adhesion kinase; NSF, N-ethylmaleimide-sensitive fusion protein; PI3K, phosphatidylinositol 3-kinase; PIP3, phosphatidylinositol 3,4,5-trisphosphate; S
Bfl-1/A1 acts as a negative regulator of autophagy in mycobacteria infected macrophages
Keywords: فسفاتیدیل اینوزیتول -3; TACO, tryptophan–aspartate containing coat protein; mTOR, mammalian target of rapamycin; PI3K, phosphatidylinositol 3-kinase; LC3, microtubule-associated protein 1 light chain 3Autophagy; Mycobacteria; Bfl-1/A1; mTOR; Rapamycin