کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2051831 | 1074211 | 2006 | 5 صفحه PDF | دانلود رایگان |
Regulation of Na+-dependent glutamate transport was studied in isolated luminal and abluminal plasma membranes derived from the bovine blood–brain barrier. Abluminal membranes have Na+-dependent glutamate transporters while luminal membranes have facilitative transporters. This organization allows glutamate to be actively removed from brain. γ-Glutamyl transpeptidase, the first enzyme of the γ-glutamyl cycle (GGC), is on the luminal membrane. Pyroglutamate (oxoproline), an intracellular product of GGC, stimulated Na+-dependent transport of glutamate by 46%, whereas facilitative glutamate uptake in luminal membranes was inhibited. This relationship between GGC and glutamate transporters may be part of a regulatory mechanism that accelerates glutamate removal from brain.
Journal: FEBS Letters - Volume 580, Issue 18, 7 August 2006, Pages 4382–4386