کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2051883 | 1074213 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hepatic stellate cell damage may lead to decreased plasma ADAMTS13 activity in rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
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چکیده انگلیسی
ADAMTS13 is gaining attention, because its deficiency causes thrombotic thrombocytopenic purpura. Although its regulatory mechanism is not fully understood, we wondered if hepatic stellate cells (HSCs) play a role, because ADAMTS13 mRNA is exclusively expressed in the liver and primarily in HSCs. Plasma ADAMTS13 activity was markedly reduced in dimethylnitrosamine-treated rats, where HSC apoptosis is an essential event, but not in carbon tetrachloride- or thioacetamide-treated rats without HSC apoptosis. Furthermore, plasma ADAMTS13 activity was also reduced in 70% hepatectomized rats, where HSC loss occurs. These results suggest that HSC may be involved in the regulation of plasma ADAMTS13 activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 8, 17 April 2007, Pages 1631–1634
Journal: FEBS Letters - Volume 581, Issue 8, 17 April 2007, Pages 1631–1634
نویسندگان
Yukio Kume, Hitoshi Ikeda, Morihiro Inoue, Kazuaki Tejima, Tomoaki Tomiya, Takako Nishikawa, Naoko Watanabe, Tatsuya Ichikawa, Makoto Kaneko, Shigeo Okubo, Hiromitsu Yokota, Masao Omata, Kenji Fujiwara, Yutaka Yatomi,