Keywords: EAS; endocrine active substances; DMN; dimethylnitrosamine; DEN; diethlynitrosamine; PAH; polyaromatic hydrocarbons; HC; histopathology credibility; MOA; mode of action; MOA; mode of action; MDHT; 17-methyldihydrotestosterone; TCDD; 2,3,7,8-tetrachlorodib
مقالات ISI (ترجمه نشده)
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Keywords: ACC; acetyl-CoA carboxylase; ASTX; astaxanthin; BAMBI; BMP and activin membrane-bound inhibitor homolog; BDL; bile duct ligation; CCL4; chemokine (C-C motif) ligand 4; CCR; chemokine receptor C-C motif; ChREBP; carbohydrate response element binding protei
Keywords: Sirt1; Sirtuin 1; DMN; dimethylnitrosamine; HO-1; Heme oxygenase -1; GST; glutathione-S-transferase; GCLC; glutathione cysteine ligase catalytic subunit; GCLM; glutathione cysteine ligase modifier subunit; Nrf2; NF-E2-related factor 2; ALT; alanine aminot
Keywords: Liver fibrosis; SOCS1; Dimethylnitrosamine; Carbon tetrachloride; Hepatic stellate cells; PDGFALT, alanine transferase; CCl4, carbon tetrachloride; DMN, dimethylnitrosamine; ECM, extra-cellular matrix; GBSS, Gey’s Balanced Salt Solution; HCC, hepatocellul
Keywords: α-SMA; α-smooth muscle actin; AST; aspartate aminotransferase; CCL2; CC-chemokine ligand 2; CCl4; carbon tetrachloride; Col I; collagen type I; CT; control; CTGF; connective tissue growth factor; DMN; dimethylnitrosamine; FCS; foetal-calf-serum; FN; fib
Keywords: Grape seed proanthocyanidins; Free radicals; DNA damage; Apoptosis; Necrosis; Multiorgan toxicity; Cancer; Vitamins C, E and β-carotene; Idarubicin; 4-Hydroxyperoxycyclophosphamide; Amiodarone; Doxorubicin; Dimethylnitrosamine
Keywords: THC; Dimethylnitrosamine; Hepatic stellate cells; Liver fibrosis; Smooth muscle actin; TGF-β1;
Keywords: lactoferrin; liver fibrosis; dimethylnitrosamine; hepatic stellate cells;
Keywords: High hydrostatic pressure; Rice; Mutagenesis; DNA strand damage; DMN; dimethylnitrosamine; HHP; high hydrostatic pressure; SDW; sterile distilled water; LMA; low-melting agarose; NMA; normal-melting agarose; ENU; ethylnitrosourea; UV; ultraviolet;
Keywords: Collagen; Dimethylnitrosamine; Hepatic stellate cells; Liver fibrosis; Matrix metalloproteinase 2; Pterostilbene; Smooth muscle actin; Transforming growth factor-β1;
Keywords: Shear wave elasticity imaging; Real-time elastography; Liver fibrosis; Dimethylnitrosamine;
Ethnopharmacology, phytochemistry, and pharmacology of Chinese Salvia species: A review
Keywords: ACh; acetylcholine; AChE; acetylcholinesterase; AD; Alzheimer's disease; AST; aspartate transaminase; CAT; catalase; CCL4; carbon tetrachloride; CK; casein kinase; DMN; dimethylnitrosamine; DPPH; 2,2-diphenyl-1-picrylhydrazyl; GSH; glutathione; HPRI; hepa
Natural product andrographolide alleviated APAP-induced liver fibrosis by activating Nrf2 antioxidant pathway
Keywords: APAP; acetaminophen; Nrf2; nuclear factor erythroid 2-related factor 2; Andro; andrographolide; HSCs; hepatic stellate cells; ROS; reactive oxygen species; ECMs; extracellular matrix proteins; Egr1; early growth factor 1; Keap1; kelch-like ECH-associated
Temsirolimus induced structural transition of cancerous renal cystatin to normal form in rats: In vitro mechanistic approach underlying renal cancer prevention
Keywords: FTIR; Fourier transformed infrared spectroscopy; RKC; rat kidney cystatin; CRKC; cancerous rat kidney cystatin; CD; circular dichroism; DMN; dimethylnitrosamine; RCC; renal cell carcinoma; mRCC; metastatic renal cell carcinoma; mTOR; mechanistic target of
Protective effect of α-lipoic acid against spleen toxicity of dimethylnitrosamine in male mice: Antioxidant and ultrastructure approaches
Keywords: Dimethylnitrosamine; α-Lipoic acid; Spleen; Tumor marker; Oxidative stress; Histopathology; Ultrastructure;
Localization of Xenobiotic Transporter OCTN1/SLC22A4 in Hepatic Stellate Cells and Its Protective Role in Liver Fibrosis
Keywords: transporters; membrane transporter; organic cation transporters (OCT); antioxidants; induction; SLC; solute carrier; ECM; extracellular matrix; NPC; nonparenchymal cells; NASH; nonalcoholic steatohepatitis; HSCs; hepatic stellate cells; OCTN1; carnitine/o
The genus Boschniakia in China: An ethnopharmacological and phytochemical review
Keywords: 5-FU; 5-Fluorouracil; β-AP; β-amiloid peptide; AD; Alzheimer disease; ALT; Alanine aminotransferase; ASC; antidepressants sensitive catalepsy; AST; Aspartate Transaminase; BC; human breast cancer; Bcl-2; B-cell lymphoma-2; bFGF; Basic fibroblast growth
Kinetics of micronucleus induction and cytotoxicity caused by distinct antineoplastics and alkylating agents in vivo
Keywords: MN-PCE; micronucleated polychromatic erythrocytes; aza-C; 5-aza-cytidine; BCNU; bis-chloroethyl-nitrosourea; BUS; busulfan; COL; colchicine; CP; cyclophosphamide; DMN; dimethylnitrosamine; ENU; ethylnitrosourea; MMC; mitomycin C; MNU; methylnitrosourea; V
Research ArticlePin1 induction in the fibrotic liver and its roles in TGF-β1 expression and Smad2/3 phosphorylation
Keywords: TGF-β1; transforming growth factor-β1; HSC; hepatic stellate cell; RT-PCR; real-time-polymerase chain reaction; MEF; mouse embryonic fibroblast; DMN; dimethylnitrosamine; α-SMA; α-smooth muscle actin; ERK; extracellular signal-regulated kinase; AP-1;
Hepatic Vascular Endothelial Growth Factor Regulates Recruitment of Rat Liver Sinusoidal Endothelial Cell Progenitor Cells
Keywords: Endothelial Progenitor Cells; Toxic Hepatitis; Animal Model; Liver Damage; ASO; antisense oligonucleotides; BM; bone marrow; DMN; dimethylnitrosamine; FACS; fluorescence-activated cell sorter; FITC; fluorescein isothiocyanate; LSEC; liver sinusoidal endot
N-acetylcysteine attenuates dimethylnitrosamine induced oxidative stress in rats
Keywords: Dimethylnitrosamine; N-acetylcysteine; Oxidative stress; Lipid peroxidation;
Evaluation of a multi-endpoint assay in rats, combining the bone-marrow micronucleus test, the Comet assay and the flow-cytometric peripheral blood micronucleus test
Keywords: Genotoxicity; Carcinogenicity; Comet assay; Bone-marrow micronucleus; Peripheral blood micronucleus; Flow cytometry; 2-Acetylaminofluorene; Benzo[a]pyrene; Carbendazim; Cyclophosphamide; Dimethylnitrosamine; Ethyl methanesulfonate; Ethyl nitrosurea; Mitom
Anti-fibrotic effects of the anthocyanins isolated from the purple-fleshed sweet potato on hepatic fibrosis induced by dimethylnitrosamine administration in rats
Keywords: Purple sweet potato; Anthocyanins; Dimethylnitrosamine; Hepatic fibrosis; α-SMA; Collagen
Research ArticleNew insights into the antifibrotic effects of sorafenib on hepatic stellate cells and liver fibrosis
Keywords: HSC; hepatic stellate cell; ECM; extracellular matrix; BDL; bile duct ligation; DMN; dimethylnitrosamine; PDGF; platelet-derived growth factor; ERK; extracellular-signal-regulated kinase; p70S6K; 70-kDa ribosomal S6 kinase; MMP; matrix metalloproteinase;
Adenovirus-mediated transfer of siRNA against PAI-1 mRNA ameliorates hepatic fibrosis in rats
Keywords: PAI-1; plasminogen activator inhibitor-1; siRNA; small interfering RNA; DMN; dimethylnitrosamine; BDL; bile duct ligation; MMPs; matrix metalloproteinases; ECM; extracellular matrix; uPA; urokinase type plasminogen activator; tPA; tissue-type plasminogen
Evaluation of the potential in vivo genotoxicity of quercetin
Keywords: 2-AAF; 2-acetylaminofluorene; Al(NO3)3; aluminium nitrate; CAS; Chemical Abstracts Service; CH3CN; acetonitrile; CGC; cytoplasmic grain counts; CPA; cyclophosphamide; DMN; dimethylnitrosamine; DNA; deoxyribonucleic acid; HPLC; high-performance liquid chro
Hepatic stellate cell damage may lead to decreased plasma ADAMTS13 activity in rats
Keywords: ADAMTS13; Hepatic stellate cell; Dimethylnitrosamine; Hepatectomy
Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity
Keywords: Autotoxin; Lysophosphatidic acid; Lysophospholipase D; Carbon tetrachloride; Dimethylnitrosamine; Hepatectomy
Study of plasma protein C and inflammatory pathways: Biomarkers for dimethylnitrosamine-induced liver fibrosis in rats
Keywords: Liver fibrosis; Dimethylnitrosamine; Protein C; sICAM-1; Biomarker; Inflammation; Chemokine; Liver enzyme; Liver histopathology
Validation of a high-throughput in vitro alkaline elution/rat hepatocyte assay for DNA damage
Keywords: AAF; 2-acetylaminofluorene; AE; alkaline elution; ATP; adenosine triphosphate; BaP; benzo[a]pyrene; BNF; β-naphthoflavone; CAS; chemical abstracts service; DABA; diaminobenzoic acid dihydrochloride; DETC; diethyldithiocarbamate; DMN; dimethylnitrosamine;
Effects of bicyclol on dimethylnitrosamine-induced liver fibrosis in mice and its mechanism of action
Keywords: Bicyclol; Dimethylnitrosamine; Hepatic fibrosis; Tumor necrosis factor-alpha; Tissue inhibitor of metalloproteinase-1; Transforming growth factor beta-1; Collagenase activity
Mineral metabolism in dimethylnitrosamine-induced hepatic fibrosis
Keywords: Dimethylnitrosamine; N-nitrosodimethylamine; Mineral metabolism; Hepatic fibrosis; Liver cirrhosis; Essential elements; Minerals; Ascites;
Negative correlation between poly-ADP-ribosylation of spleen cell histone proteins and initial duration of dimethylnitrosamine exposure to mice in vivo measured by Western blot immunoprobe assay: a possible biomarker for cancer detection
Keywords: Cancer biomarker; Poly-ADP-ribosylation; Dimethylnitrosamine; Spleen; Western blot immunoprobe assay; Histone proteins; Mice;
Suppression of macrophage infiltration inhibits activation of hepatic stellate cells and liver fibrogenesis in rats
Keywords: DMN; dimethylnitrosamine; ELISA; enzyme-linked immunosorbent assay; HSC; hepatic stellate cells; MCP; monocyte chemoattractant protein; MOI; multiplicity of infection; TGF; transforming growth factor; TUNEL; terminal deoxynucleotidyl transferase-mediate