کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5848591 1561699 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation
ترجمه فارسی عنوان
دایسونین آسیب حاد کبدی ناشی از دی متیل ناترواسیمین را کاهش می دهد از طریق تنظیم آپوپتوز، استرس اکسیداتیو و التهاب
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


- Dioscin showed potent effect against DMN-induced acute liver injury.
- Dioscin regulated TLR4/MyD88 signal pathway to suppress inflammation.
- Dioscin regulated Sirt1/Nrf2 signal pathway to suppress oxidative stress.
- Dioscin regulated IRF9 level to inhibit apoptosis.

In our previous study, the effects of dioscin against alcohol-, carbon tetrachloride- and acetaminophen-induced liver damage have been found. However, the activity of it against dimethylnitrosamine (DMN)-induced acute liver injury remained unknown. In the present study, dioscin markedly decreased serum ALT and AST levels, significantly increased the levels of SOD, GSH-Px, GSH, and decreased the levels of MDA, iNOS and NO. Mechanism study showed that dioscin significantly decreased the expression levels of IL-1β, IL-6, TNF-α, IκBα, p50 and p65 through regulating TLR4/MyD88 pathway to rehabilitate inflammation. In addition, dioscin markedly up-regulated the expression levels of SIRT1, HO-1, NQO1, GST and GCLM through increasing nuclear translocation of Nrf2 against oxidative stress. Furthermore, dioscin significantly decreased the expression levels of FasL, Fas, p53, Bak, Caspase-3/9, and upregulated Bcl-2 level through decreasing IRF9 level against apoptosis. In conclusion, dioscin showed protective effect against DMN-induced acute liver injury via ameliorating apoptosis, oxidative stress and inflammation, which should be developed as a new candidate for the treatment of acute liver injury in the future.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 45, July 2016, Pages 193-201
نویسندگان
, , , , , , , , ,