کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2051884 1074213 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synergistic action of polyanionic and non-polar cofactors in fibrillation of human islet amyloid polypeptide
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Synergistic action of polyanionic and non-polar cofactors in fibrillation of human islet amyloid polypeptide
چکیده انگلیسی

Recent studies have led us to suppose that synergistic action of multiple solute cofactors could play substantial roles in amyloid-type fibrillogenesis of pathogenic polypeptides. To support this view, we performed aggregation experiments of human islet amyloid polypeptide (IAPP) in media containing both polyanions and non-polar solvents. The results demonstrated that the fibrillation at sub-micromolar IAPP occurred only when polyanionic and non-polar solutes coexist. A simple sum of two independent cofactor’s effects could not account for the synergistic action. We propose that this synergy of polyanionic and nonpolar milieus could substantially modify the amyloidgenesis in the human body.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 8, 17 April 2007, Pages 1635–1638
نویسندگان
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