Keywords: ThT، Thioflavin T; Alzheimer’s disease; Beta-amyloid; Palladium-catalyzed aminations; HydrazineAD, Alzheimer’s disease; Aβ, amyloid beta; ThT, Thioflavin T; bio-Aβ42, N-α-biotinyl-Aβ (1–42); SAR, structure activity relationship; OFB, oligomer formation buffer
مقالات ISI ThT، Thioflavin T (ترجمه نشده)
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Keywords: ThT، Thioflavin T; Amyloid; Length distribution; Differential centrifugation; Aβ peptide; Polydispersity; Size distributionAFM, atomic force microscopy; Aβ42, amyloid β (M1–42) peptide; EDTA, ethylenediaminetetraacetic acid; ThT, thioflavin T; cryo-TEM, cryogenic transmissi
Keywords: ThT، Thioflavin T; ThT, thioflavin T; SDS-PAGE, sodium dodecyl sulfate polyacrylamide gel electrophoresis; TEM, transmission electron microscopy; IPTG, isopropyl β-d-1-thiogalactopyranoside; GSK-3β, glycogen synthase kinase; DTT, dl-dithiothreitolTau protein; Alzheimer's di
Keywords: ThT، Thioflavin T; RCMκ-CN, reduced and carboxymethylated κ-casein; GS, ginsenosides; Rg1, ginsenoside Rg1; Rb1, ginsenoside Rb1; Re, ginsenoside Re; AD, Alzheimer's disease; PD, Parkinson's disease; HD, Huntington's disease; ThT, thioflavin T; RLS, resonance light scatteri
Keywords: ThT، Thioflavin T; ANS, 1-anilino-8-napthalene sulfonate; CA, conalbumin; HFIP, 1,1,1,3,3,3-hexafluoro-propan-2-ol; TEM, transmission electron microscope; ThT, Thioflavin T; TFE, 2,2,2-trifuoroethanolAmyloid fibrils; Conalbumin; Circular dichroism; Transmission electron mic
Keywords: ThT، Thioflavin T; PET, Positron Emission Tomography; MRI, Magnetic Resonance Imaging; ThT, Thioflavin T; TEM, Transmission Electron Microscope
Nuclear magnetic resonance evidence for the dimer formation of beta amyloid peptide 1–42 in 1,1,1,3,3,3-hexafluoro-2-propanol
Keywords: ThT، Thioflavin T; Amyloid beta; HFIP; Solution NMR; Self-association; Alzheimer's diseaseAD, Alzheimer's disease; Aβ, amyloid beta; ThT, thioflavin T; NMR, nuclear magnetic resonance; HFIP, 1,1,1,3,3,3-hexafluoro-2-propanol; IB, inclusion body; HPLC, high-performance liqui
Peptides Composed of Alternating L- and D-Amino Acids Inhibit Amyloidogenesis in Three Distinct Amyloid Systems Independent of Sequence
Keywords: ThT، Thioflavin T; Aβ42, amyloid Beta (1–42); IAPP, islet amyloid polypeptide; NOESY, nuclear Overhauser effect spectroscopy; TTR, transthyretin; ThT, Thioflavin T; CR, Congo red; CD, circular dichroism spectroscopy; FTIR, Fourier Transform Infrared; HFIP, hexafluoro – 1, 1
The green tea polyphenol (−)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios
Keywords: ThT، Thioflavin T; AD, Alzheimer’s disease; EGCG, (−)-epigallocatechin gallate; ThT, Thioflavin T; PCR, polymerase chain reaction; NBT, nitroblue tetrazolium; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; AFM, atomic force microscopyTau protein; Tau oli
Effect of amino acid variations in the central region of human serum amyloid A on the amyloidogenic properties
Keywords: ThT، Thioflavin T; CD, circular dichroism; SAA, serum amyloid A; ThT, thioflavin T; TEM, transmission electron microscopyAmino acid variation; Amyloid fibril formation; Fibril morphology; Serum amyloid A; Synthetic fragment peptide
Induction of amyloidogenicity in wild type HEWL by a dialdehyde: Analysis involving multi dimensional approach
Keywords: ThT، Thioflavin T; HEWL, hen egg white lysozyme; ANS, 8-anilino-1-naphthalenesulphonic acid; FT-IR, Fourier transform infra red; CML, carboxy methyl lysine; CMA, carboxy methyl arginine; CR, Congo red; ThT, Thioflavin T; TEM, transmission electron microscopeAbsorbance; Aggr
Detergent induces the formation of IgG aggregates: A multi-methodological approach
Keywords: ThT، Thioflavin T; ANS, 8-anilino-1-naphthalene-sulphonic acid; BIgG, bovine IgG; CD, circular dichroism; CR, congo red; DLS, dynamic light scattering; HIgG, human IgG; IgG, immunoglobulin G; MG, molten globule; ThT, Thioflavin T; TX-100, Triton X-100Aggregation; CHAPSO; Dy
Amyloid-β(1-42) protofibrils stimulate a quantum of secreted IL-1β despite significant intracellular IL-1β accumulation in microglia
Keywords: ThT، Thioflavin T; AD, Alzheimer’s disease; Aβ, amyloid-β protein; aCSF, artificial cerebrospinal fluid; HFIP, hexafluoroisopropanol; IL-1β, interleukin-1β; SEC, size exclusion chromatography; ThT, thioflavin T; TNFα, tumor necrosis factor αAmyloid-beta protein; Protofibril
The missing link in the amyloid cascade of Alzheimer’s disease – Metal ions
Keywords: ThT، Thioflavin T; Aβ, amyloid-β peptide; AD, Alzheimer’s disease; APOE, apolipoprotein E; APP, amyloid precursor protein; BBB, blood–brain-barrier; CFS, cerebrospinal fluid; CQ, clioquinol; ThT, thioflavin T; NFT, neurofibrillary tanglesAlzheimer’s disease; Amyloid beta; M
Identification of an amyloid fibril forming peptide comprising residues 46–59 of apolipoprotein A-I
Keywords: ThT، Thioflavin T; ApoA-I, apolipoprotein A-I; HDL, high density lipoprotein; RCT, reverse cholesterol transport; ThT, thioflavin T; HPLC, high performance liquid chromatography; CD, circular dichroism; TEM, transmission electron microscopyProtein misfolding; Aggregation; P
Identification of distinct physiochemical properties of toxic prefibrillar species formed by Aβ peptide variants
Keywords: ThT، Thioflavin T; AD, Alzheimer’s disease; Aβ, amyloid-β peptide; APP, amyloid precursor protein; TEM, transmission electron microscopy; ANS, 8-anilino-1-napthalensulfonate; ThT, thioflavin T; p-FTAA, pentamer formyl thiophene acetic acid; pFTAA+ species, species recognize
Inhibitory effects of choline-O-sulfate on amyloid formation of human islet amyloid polypeptide
Keywords: ThT، Thioflavin T; COS, choline-O-sulfate; hIAPP, human islet amyloid polypeptide; NDSB, non-detergent sulfobetaine; HFIP, 1,1,1,3,3,3-hexafluoro-2-propanol; ThT, thioflavin T; CD, circular dichroism; TEM, transmission electron microscopyOsmolyte; Choline-O-sulfate; Aggrega
A multifunctional peptide rescues memory deficits in Alzheimer's disease transgenic mice by inhibiting Aβ42-induced cytotoxicity and increasing microglial phagocytosis
Keywords: ThT، Thioflavin T; AD, Alzheimer's disease; Aβ, β-amyloid peptide; MTT, 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide; ThT, thioflavin T; SDS-PAGE, sodium dodecyl sulfate-polyacrylamide gel electrophoresis; TEM, transmission electron microscope; APP, β-amyloi
Synthesis and in vitro evaluation of α-synuclein ligands
Keywords: ThT، Thioflavin T; PD, Parkinson’s disease; AD, Alzheimer’s disease; LBs, Lewy bodies; LNs, Lewy neuritis; CNS, central nervous system; DMF, dimethylformamide; DMSO, dimethyl sulfoxide; SDS–PAGE, sodium dodecyl sulfate polyacrylamide gel electrophoresis; ThT, thioflavin T;
Metal ions and amyloid fiber formation in neurodegenerative diseases. Copper, zinc and iron in Alzheimer's, Parkinson's and prion diseases
Keywords: ThT، Thioflavin T; Aβ, amyloid-β-peptide; AD, Alzheimer's disease; CD, circular dichroism; NMDAR, N-methyl-d-aspartate receptors; PD, Parkinson's disease; PrP, prion protein; αSyn, α-synuclein; ThT, thioflavin T; TSEs, transmissible spongiform encephalopathies; TEM, transmi
Oligomeric Intermediates in Amyloid Formation: Structure Determination and Mechanisms of Toxicity
Keywords: ThT، Thioflavin T; AD, Alzheimer's disease; PD, Parkinson's disease; CR, Congo red; ThT, thioflavin T; EM, electron microscopy; FCS, fluorescence correlation spectroscopy; ANS, 1-anilino-8-naphthalene sulfonate; MD, molecular dynamics; ROS, reactive oxygen species; MTT, 3-(
Glycosaminoglycans (GAGs) Suppress the Toxicity of HypF-N Prefibrillar Aggregates
Keywords: ThT، Thioflavin T; GAG, glycosaminoglycan; HypF-N, N-terminal domain of Escherichia coli HypF; Aβ, amyloid β; IAPP, islet amyloid polypeptide; CHO, Chinese hamster ovarian; TFE, trifluoroethanol; ThT, thioflavin T; HS, heparan sulfate; DS, dermatan sulfate; MTT, 3-(4,5-dime
Multiple Roles of Heparin in the Aggregation of p25α
Keywords: ThT، Thioflavin T; αSN, α-synuclein; PD, Parkinson's disease; PDB, Protein Data Bank; GAG, glycosaminoglycan; ThT, thioflavin T; HW, high molecular weight; AFM, atomic force microscopy; PBS, phosphate-buffered saline; CAC, critical aggregation concentration; DP, degree of p
The hexapeptide PGVTAV suppresses neurotoxicity of human α-synuclein aggregates
Keywords: ThT، Thioflavin T; PD, Parkinson’s disease; DMEM, Dulbecco’s Modified Eagle’s Medium; FBS, fetal bovine serum; HBSS, Hank’s balanced salt solution; LDH, lactate dehydrogenase; PI, propidium iodide; ThT, thioflavin T; TH, tyrosine hydroxylasePeptide inhibitor; Amyloidosis; F
Both plant and animal LEA proteins act as kinetic stabilisers of polyglutamine-dependent protein aggregation
Keywords: ThT، Thioflavin T; LEA, late embryogenesis abundant; PBS, phosphate-buffered saline; IDP, intrinsically disordered protein; EGFP, enhanced green fluorescent protein; GST, glutathione transferase; ThT, thioflavin T; polyQ, polyglutamine; FRET, Förster resonance energy transf
Ultrasonication-Dependent Acceleration of Amyloid Fibril Formation
Keywords: ThT، Thioflavin T; β2-m, β2-microglobulin; ThT, thioflavin T; AFM, atomic force microscopyamyloid fibrils; β2-microglobulin; high-throughput assay; microplate reader; ultrasonication
Membrane Integrity and Amyloid Cytotoxicity: A Model Study Involving Mitochondria and Lysozyme Fibrillation Products
Keywords: ThT، Thioflavin T; HEWL, hen egg white lysozyme; ThT, thioflavin T; ANS, 1-anilino-naphthalene 8-sulfonate; SEC, size-exclusion chromatography; DLS, dynamic light scattering; TEM, transmission electron microscopy; MDH, malate dehydrogenase; GDH, glutamate dehydrogenase; CS,
Potent inhibitors of amyloid β fibrillization, 4,5-dianilinophthalimide and staurosporine aglycone, enhance degradation of preformed aggregates of mutant Notch3
Keywords: ThT، Thioflavin T; CADASIL, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy; ER, endoplasmic reticulum; DAPH, 4,5-dianilinophthalimide; SA, staurosporine aglycone; Aβ, amyloid β; ThT, thioflavin T; VSMCs, vascular smooth muscle cel
DnaK/DnaJ/GrpE of Hsp70 system have differing effects on α-synuclein fibrillation involved in Parkinson's disease
Keywords: ThT، Thioflavin T; PD, Parkinson's disease; α-Syn, alpha-synuclein; ThT, Thioflavin T; Hsp70, heat shock protein 70; RCMLA, reduced carboxymethylated lactalbumin; TMAO, triethylamine N-oxideα-Synuclein; Chaperones; DnaK; DnaJ; GrpE; Parkinson's; Amyloid
Chemical modification of lysine residues in lysozyme may dramatically influence its amyloid fibrillation
Keywords: ThT، Thioflavin T; HEWL, hen egg white lysozyme; ThT, thioflavin T; ANS, 8-anillino-1-naphthalene-sulfonic acid; TEM, transmission electron microscopy; Ac-HEWL, acetylated HEWL; Ac-Lys, acetylated lysine; Cit-HEWL, citraconylated-HEWL; Cit-Lys, citraconylated-lysine; 4-MU-β
Alpha-tocopherol quinone inhibits beta-amyloid aggregation and cytotoxicity, disaggregates preformed fibrils and decreases the production of reactive oxygen species, NO and inflammatory cytokines
Keywords: ThT، Thioflavin T; AD, Alzheimer's disease; Aβ, beta-amyloid peptide; CD, circular dichroism; NO, nitric oxide; DCFH-DA, 2′,7′-dichlorfluorescein-diacetate; α-TQ, RRR-α-tocopherol quinone; α-T, RRR-α-tocopherol; ThT, thioflavin T; HFIP, 1,1,1,3,3,3-hexafluoro-2-propanol; MT
Thioflavin T fluorescence in human serum: Correlations with vascular health and cardiovascular risk factors
Keywords: ThT، Thioflavin T; ThT, Thioflavin T; apo, apolipoprotein; RA, rheumatoid arthritis; SLE, systemic lupus erythematosis; AGE, advanced glycation end-product; CV, coefficient of variance; NS, not significant; HSA, human serum albumin; SAE, small artery elasticity; CRP, C-reac
Vortex-Induced Formation of Insulin Amyloid Superstructures Probed by Time-Lapse Atomic Force Microscopy and Circular Dichroism Spectroscopy
Keywords: ThT، Thioflavin T; ICD, induced circular dichroism; ThT, thioflavin T; rpm, rounds per minute; AFM, atomic force microscopy; LD, linear dichroismamyloid; vortex forces; superstructures; polymorphism; chirality
A Single Mutation at the Sheet Switch Region Results in Conformational Changes Favoring λ6 Light-Chain Fibrillogenesis
Keywords: ThT، Thioflavin T; ASU, asymmetric unit; BJ, Bence–Jones; CDR, complementarity-determining region; FR, framework region; LC, light chain; PBS, phosphate-buffered saline; PCR, polymerase chain reaction; ThT, thioflavin T; VL, variable region of the light chain; WT, wild type
Towards Multiparametric Fluorescent Imaging of Amyloid Formation: Studies of a YFP Model of α-Synuclein Aggregation
Keywords: ThT، Thioflavin T; AS, α-synuclein; YFP, yellow fluorescent protein; FAIM, fluorescence anisotropy imaging microscopy; ThT, thioflavin T; TEM, transmission electron microscopy; CR, Congo red; HSQC, heteronuclear single quantum coherence; BS, β-synuclein; GFP, green fluoresc
Structure and Properties of a Complex of α-Synuclein and a Single-Domain Camelid Antibody
Keywords: ThT، Thioflavin T; IDP, intrinsically disordered protein; ITC, isothermal titration calorimetry; ANS, 1-anilino-8-naphthalene sulfonate; ThT, thioflavin T; TEM, transmission electron microscopy; ASA, solvent-accessible surface area; HSQC, heteronuclear single quantum cohere
Biosynthesis and characterization of typical fibroin crystalline polypeptides of silkworm Bombyx mori
Keywords: ThT، Thioflavin T; Fib-H, silk fibroin heavy chain; Fib-L, silk fibroin light chain; ThT, thioflavin T; GST, glutathione transferase; G, Gly; A, Ala; S, Ser; Y, Tyr; V, Val; L, Leu; P, Pro; R, ArgFibroin crystalline; Silkworm; Genes; Fusion protein; Thrombin; ThT
β-Sheet-breaking peptides inhibit the fibrillation of human α-synuclein
Keywords: ThT، Thioflavin T; PD, Parkinson’s disease; AD, Alzheimer’s disease; ThT, thioflavin T; TEM, transmission electron microscopy; PBS, phosphate-buffered salineConformational switch; Peptide inhibitors; Protein amyloid; Protein fibrils; α-Synuclein
A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-β
Keywords: ThT، Thioflavin T; AD, Alzheimer’s disease; Aβ, amyloid-β peptide; HCR, hydrophobic core region; TEM, transmission electron microscopy; AFM, atomic force microscopy; LMW, low molecular weight; 5-MI-2-CA, 5-methylindole-2-carboxylic acid; CR, Congo Red; ThT, thioflavin T; PE
Interactions of thioflavin T with serum albumins: Spectroscopic analyses
Keywords: ThT، Thioflavin T; ThT, thioflavin T; HSA, human serum albumin; BSA, bovine serum albumin; PSA, porcine serum albumin; RSA, rabbit serum albumin; ITC, isothermal titration calorimetryDelta H; Delta S; Protein–ligand interaction; Serum albumins; Thioflavin T
A single mutation in an SH3 domain increases amyloid aggregation by accelerating nucleation, but not by destabilizing thermodynamically the native state
Keywords: ThT، Thioflavin T; Spc-SH3, Src-homology 3 domain of α-spectrin; DSC, differential scanning calorimetry; ThT, thioflavin T; DLS, dynamic light scattering; TEM, transmission electron microscopyAmyloid; Thermodynamics; Protein stability; Differential scanning calorimetry; Dyn
Essential role of Pro 74 in stefin B amyloid-fibril formation: Dual action of cyclophilin A on the process
Keywords: ThT، Thioflavin T; TFE, 2,2,2-trifluoroethanol; TEM, transmission electron microscopy; ThT, thioflavin T; PPI, peptidyl-prolyl-cis/trans isomerase; CAB, carbonic anhydrase B; CD, circular dichroismStefin B; Amyloid fibril; Proline cis/trans isomerism; Cyclophilin A; Kinetic
Amyloid β (1–42) Folding Multiplicity and Single-Molecule Binding Behavior Studied with STM
Keywords: ThT، Thioflavin T; Aβ, amyloid β; XRD, X-ray diffraction; STM, scanning tunneling microscopy; AFM, atomic force microscopy; HOPG, highly oriented pyrolytic graphite; 2D, two-dimensional; CR, Congo red; ThT, thioflavin T; 3D, three-dimensionalAβ42; assembly structures; singl
Suppression of lysozyme aggregation at alkaline pH by tri-N-acetylchitotriose
Keywords: ThT، Thioflavin T; HEWL, hen egg white lysozyme; chitotriose, N,N′,N″-Triacetylchitotriose; ThT, Thioflavin T; ANS, 8-Anilino-1-naphthalene sulfonic acid; NAG, N-Acetyl-d-glucosamine; SDS, sodium dodecyl sulfate; SDS-PAGE, SDS polyacrylamide gel electrophoresis; DTT, dithio
A New Amyloid-Like β-Aggregate with Amyloid Characteristics, Except Fibril Morphology
Keywords: ThT، Thioflavin T; Aβ, amyloid β; APP, amyloid precursor protein; ThT, thioflavin T; CR, Congo red; PBS, phosphate-buffered saline; MTT, 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromideamyloid; fibril; aggregate; Alzheimer; Aβ
Structural Insights into Alternate Aggregated Prion Protein Forms
Keywords: ThT، Thioflavin T; rec, recombinant; PrP, prion protein; PrPC, cellular form of prion protein; PrPSc, scrapie prion protein; ASA, amyloid seeding assay; GdnHCl, guanidine hydrochloride; ThT, thioflavin T; PTA, phosphotungstate; AFM, atomic force microscopyprion protein (PrP
Resveratrol inhibits beta-amyloid oligomeric cytotoxicity but does not prevent oligomer formation
Keywords: ThT، Thioflavin T; AD, Alzheimer's disease; Aβ, beta-amyloid peptide; fAβ, beta-amyloid fibril; ThT, thioflavin T; Res, resveratrol; SDS-PAGE, sodium dodecyl sulfate-polyacrylamide gel electrophoresis; CD, circular dichroism; TEM, transmission electron microscope; MTT, 3-(4
Cholesterol Regulates Assembly of Human Islet Amyloid Polypeptide on Model Membranes
Keywords: ThT، Thioflavin T; AFM, atomic force microscopy; DOPC, 1,2-dioleoyl phosphatidylcholine; IAPP, islet amyloid polypeptide; ThT, thioflavin T; PC, phosphatidylcholine; PM, plasma membrane; PS, phosphatidylserine; HFIP, hexafluoride isopropanolamylin; cholesterol; membranes; A
Conformational Conversion May Precede or Follow Aggregate Elongation on Alternative Pathways of Amyloid Protofibril Formation
Keywords: ThT، Thioflavin T; HOI, higher oligomeric intermediate; AFM, atomic force microscopy; ThT, thioflavin T; wt, wild type; DLS, dynamic light scatteringbarstar; amyloid protofibrils; soluble oligomers; conformational conversion; alternative pathways
Ca2+, within the physiological concentrations, selectively accelerates Aβ42 fibril formation and not Aβ40 in vitro
Keywords: ThT، Thioflavin T; ThT, Thioflavin T; Aβ40, Amyloid beta peptide 1–40; Aβ42, Amyloid beta peptide 1–42; CD, Circular dichroism; EM, Electron micrograph; AD, Alzheimer's diseaseAβ40; Aβ42; Calcium; Amyloid; Alzheimer's