کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1933183 1050605 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
β-Sheet-breaking peptides inhibit the fibrillation of human α-synuclein
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
β-Sheet-breaking peptides inhibit the fibrillation of human α-synuclein
چکیده انگلیسی

α-Synuclein is the major components of the intracellular protein-aggregates, found in the dopaminergic neurons of Parkinson’s disease patients. Previously, we screened for α-synuclein substitution mutants that prevent fibril formation of both wild-type and Parkinson’s disease-linked α-synuclein variants. In the present study, we show that short synthetic peptides derived from these mutant sequences not only prevented α-synuclein fibrillation but also dissolved preformed α-synuclein aggregates in vitro. The hexapeptide PGVTAV, which was the shortest peptide that retained the ability to block α-synuclein fibrillation, may serve as a lead compound for the development of therapeutics for Parkinson’s disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 387, Issue 4, 2 October 2009, Pages 682–687
نویسندگان
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