کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1933183 | 1050605 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
β-Sheet-breaking peptides inhibit the fibrillation of human α-synuclein
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: β-Sheet-breaking peptides inhibit the fibrillation of human α-synuclein β-Sheet-breaking peptides inhibit the fibrillation of human α-synuclein](/preview/png/1933183.png)
چکیده انگلیسی
α-Synuclein is the major components of the intracellular protein-aggregates, found in the dopaminergic neurons of Parkinson’s disease patients. Previously, we screened for α-synuclein substitution mutants that prevent fibril formation of both wild-type and Parkinson’s disease-linked α-synuclein variants. In the present study, we show that short synthetic peptides derived from these mutant sequences not only prevented α-synuclein fibrillation but also dissolved preformed α-synuclein aggregates in vitro. The hexapeptide PGVTAV, which was the shortest peptide that retained the ability to block α-synuclein fibrillation, may serve as a lead compound for the development of therapeutics for Parkinson’s disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 387, Issue 4, 2 October 2009, Pages 682–687
Journal: Biochemical and Biophysical Research Communications - Volume 387, Issue 4, 2 October 2009, Pages 682–687
نویسندگان
You Soon Kim, Dongyeol Lim, Joo Yeon Kim, Shin Jung Kang, Yang-Hee Kim, Hana Im,