کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2200674 1099960 2013 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The missing link in the amyloid cascade of Alzheimer’s disease – Metal ions
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
The missing link in the amyloid cascade of Alzheimer’s disease – Metal ions
چکیده انگلیسی

Progressive deposition of amyloid beta (Aβ) peptides into amyloid plaques is the pathological hallmark of Alzheimer’s disease (AD). The amyloid cascade hypothesis pins this deposition as the primary cause of the disease, but the mechanisms that causes this deposition remain elusive. An increasing amount of evidence shows that biometals Zn(II) and Cu(II) can interact with Aβ, thus influencing the fibrillization and toxicity. This review focuses on the role of Zn(II) and Cu(II) in AD, and revisits the amyloid cascade hypothesis demonstrating the possible roles of Zn(II) and Cu(II) in the disease pathogenesis.

Figure optionsDownload as PowerPoint slideHighlights
► Binding of Zn(II) and Cu(II) to Aβ has a complex effect on Aβ fibrillization.
► Amyloid cascade in AD may be triggered by metal (zinc and/or copper) ions.
► The toxicity of amyloid fibrils is caused by the content of redox-active metal ions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurochemistry International - Volume 62, Issue 4, March 2013, Pages 367–378
نویسندگان
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