کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2051911 | 1074214 | 2006 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The multidrug resistance-associated protein (MRP/ABCC) subfamily of ATP-binding cassette transporters in plants The multidrug resistance-associated protein (MRP/ABCC) subfamily of ATP-binding cassette transporters in plants](/preview/png/2051911.png)
In many different plant species, genes belonging to the multidrug resistance-associated protein (MRP, ABCC) subfamily of ABC transporters have been identified. Following the discovery of vacuolar transport systems for xenobiotic or plant-produced conjugated organic anions, plant MRPs were originally proposed to be primarily involved in the vacuolar sequestration of potentially toxic metabolites. Indeed, heterologous expression of different Arabidopsis MRPs in yeast demonstrates their activity as ATP-driven pumps for structurally diverse substrates. Recent analysis of protein–protein interactions and the characterization of knockout mutants in Arabidopsis suggests that apart from transport functions plant MRPs play additional roles including the control of plant transpiration through the stomata. Here, we review and discuss the diverse functions of plant MRP-type ABC transporters and present an organ-related and developmental analysis of the expression of Arabidopsis MRPs using the publicly available full-genome chip data.
Journal: FEBS Letters - Volume 580, Issue 4, 13 February 2006, Pages 1112–1122