کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2051950 1074217 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Involvement of AMP-activated protein kinase in fat depot-specific metabolic changes during starvation
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Involvement of AMP-activated protein kinase in fat depot-specific metabolic changes during starvation
چکیده انگلیسی

The mechanisms controlling fat depot-specific metabolism are poorly understood. During starvation of mice, downregulation of lipogenic genes, suppression of fatty acid synthesis, and increases in lipid oxidation were all more pronounced in epididymal than in subcutaneous fat. In epididymal fat, relatively strong upregulation of uncoupling protein 2 and phosphoenolpyruvate carboxykinase genes was found. In mice maintained both at 20 and 30 °C, AMP-activated protein kinase was activated in epididymal but did not change in subcutaneous fat. Our results suggest that AMPK may have a role in the different response of various fat depots to starvation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 579, Issue 27, 7 November 2005, Pages 6105–6110
نویسندگان
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