کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2051984 | 1074218 | 2007 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Huperzine A protects C6 rat glioma cells against oxygen–glucose deprivation-induced injury Huperzine A protects C6 rat glioma cells against oxygen–glucose deprivation-induced injury](/preview/png/2051984.png)
The protective effects of huperzine A against oxygen–glucose deprivation (OGD)-induced injury in C6 cells were investigated. OGD for 6 h and reoxygenation for 6 h enhanced phosphorylation and degradation of IκBα and nuclear translocation of nuclear factor-kappa B (NF-κB), triggered overexpression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and nitric oxide (NO) in C6 cells. Along with inhibiting acetylcholinesterase activity, treatment with 1 μM huperzine A inhibited activation of NF-κB, attenuated iNOS, COX-2 and NO overexpression, and promoted survival in C6 cells subjected to OGD insult. The protective effects of huperzine A were partly mediated by “cholinergic anti-inflammatory pathway” through α7 nicotinic acetylcholine receptor.
Journal: FEBS Letters - Volume 581, Issue 4, 20 February 2007, Pages 596–602