کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2052205 1074224 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The identification of a functional interaction between PKC and topoisomerase II
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
The identification of a functional interaction between PKC and topoisomerase II
چکیده انگلیسی

Topoisomerase II plays an essential role in the segregation of chromosomes during cell division. It is also a major component of the nuclear matrix. Proteins that interact with and regulate this essential enzyme are of great interest. To investigate the role of proteins interacting with the N-terminal domain of the Saccharomyces cerevisiae topoisomerase II, we used a yeast two-hybrid protein interaction screen. We identified an interaction between the catalytic domain of the yeast protein kinase 1 enzyme (Pkc1) and the N-terminal domain of the S. cerevisiae topoisomerase II. The S. cerevisiae Pkc1 is the homologue of the mammalian calcium dependent PKC.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 580, Issue 1, 9 January 2006, Pages 51–57
نویسندگان
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