Keywords: Disinfection by-products; Mammalian cell toxicity; Topoisomerase II; Mitosis inhibition; Cell cycle disruption;
مقالات ISI (ترجمه نشده)
مقالات زیر هنوز به فارسی ترجمه نشده اند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: Benzoquinolines; Microwave chemistry; Synthesis; DNA; Topoisomerase II;
Keywords: Evodiamine derivatives; Topoisomerase I; Topoisomerase II; Asymmetric synthesis; Antitumor activity
Keywords: HSPC; hematopoietic stem and progenitor cells; APH; aphidicolin; PBS; phosphate-buffered saline; DEN; diethylnitrosamine; BCR; breakpoint cluster region; LM-PCR; ligation-mediated PCR; CBFB; Fragile site; Hematopoietic stem cells; Leukemia; MLL; Topoisome
Keywords: VZHGLHMHIIZMQE-XCCZJJLVSA-N; RKUKDXPXERQSDB-IJIAAYELSA-N; LUVGOMDSWULCGD-ABLRHOQDSA-N; IZTBKTHEDFZDJY-WAZWUXIFSA-N; WEIVKVIMBFRZNP-LYIFVQRYSA-N; NRMDQWTWRPTGQW-GKMJJFNSSA-N; AWAXXNITJSMXPD-OYQJTXMHSA-N; GRLCXUMXOFMFDC-FTHPFZORSA-N; ACN; acetonitrile; Boc;
Keywords: Alnus glutinosa; Diarylheptanoid; Cytotoxicity; Hirsutanone; Topoisomerase II; Reactive oxygen species;
Keywords: Antibacterial; Antimicrobial; Topoisomerase II; Phenotypic screening; Discovery strategy;
Keywords: 3C; chromosome conformation capture; Abd-B; Abdominal-B; AGO2; Argonaute 2; ANT-C; Antennapedia complex; BEAF-32; boundary element-associated factor of 32Â kDa; BTB; broad-complex, tramtrack, bric-a-brac; BX-C; bithorax complex; ChIP; chromatin immunoprec
Keywords: Bisindolylalkane; Anticancer; Topoisomerase II; Indole; Thiochroman-4-one;
Synthesis and biological evaluation of novel carbazole-rhodanine conjugates as topoisomerase II inhibitors
Keywords: Carbazole; Rhodanine; Topoisomerase II; Cytotoxic; Hybrid molecule;
Probing the evolutionary conserved residues Y204, F259, S400 and W590 that shape the catalytic groove of human TDP1 for 3â²- and 5â²-phosphodiester-DNA bond cleavage
Keywords: hTDP1; human tyrosyl-DNA phosphodiesterase 1; TOP1; topoisomerase I; TOP2; topoisomerase II; TOP1cc; TOP1 cleavage complex; TOP2cc; TOP2 cleavage complex; DNA damage and repair; 3â²-End blocking DNA lesions; 5â²-End blocking DNA lesions; Topoisomerases;
Co(III) complexes based on α-N-heterocyclic thiosemicarbazone ligands: DNA binding, DNA cleavage, and topoisomerase I/II inhibitory activity studies
Keywords: Thiosemicarbazones; Cobalt(III) complexes; Topoisomerase I; Topoisomerase II; DNA interactions;
Novel ciprofloxacin hybrids using biology oriented drug synthesis (BIODS) approach: Anticancer activity, effects on cell cycle profile, caspase-3 mediated apoptosis, topoisomerase II inhibition, and antibacterial activity
Keywords: Ciprofloxacin; Biology oriented drug synthesis (BIODS); Anticancer activity; Topoisomerase II; Cell cycle arrest profile; Caspase-3; Apoptosis; Antibacterial activity;
Design, synthesis, molecular modeling and anti-proliferative evaluation of novel quinoxaline derivatives as potential DNA intercalators and topoisomerase II inhibitors
Keywords: Anticancer; DNA-Intercalator; Molecular docking; Quinoxaline derivatives; Topoisomerase II;
Synthesis of carbazole derivatives containing chalcone analogs as non-intercalative topoisomerase II catalytic inhibitors and apoptosis inducers
Keywords: Carbazole; Chalcone; Topoisomerase II; Cytotoxic; Apoptosis;
Isolation and structure elucidation of flavonoids from Amburana cearensis resin and identification of human DNA topoisomerase II-α inhibitors
Keywords: Amburana cearensis; Flavonoids; Topoisomerase II;
Enhanced B-Raf-mediated NRF2 gene transcription and HATs-mediated NRF2 protein acetylation contributes to ABCC1-mediated chemoresistance and glutathione-mediated survival in acquired topoisomerase II poison-resistant cancer cells
Keywords: ABC; ATP-binding cassette; ABCC; The ABC subfamily C; ABCC1; ATP-binding cassette subfamily C member 1; AHR; aryl hydrocarbon receptor; AKR1C1; aldo-keto reductase family 1 member C1; AREs; antioxidant-responsive elements; B-Raf; B-Raf proto-oncogene, ser
Synthesis of novel C4-benzazole naphthalimide derivatives with potent anti-tumor properties against murine melanoma
Keywords: Benzazole; B16F10 cells; Melanoma; MTS assay; Naphthalimide; Topoisomerase II;
Synthesis and biological evaluation of naphthoquinone-coumarin conjugates as topoisomerase II inhibitors
Keywords: 2-Hydroxynaphthoquinone; 4-Hydroxycoumarin; Privileged structures; Topoisomerase II; ATPase; Docking;
Inhibition of Plasmodium falciparum proliferation in vitro by double-stranded RNA nanoparticle against malaria topoisomerase II
Keywords: Plasmodium falciparum; Malaria; Double-stranded RNA; Nanoparticles; Topoisomerase II; PfTOP2
Nitric oxide inhibits topoisomerase II activity and induces resistance to topoisomerase II-poisons in human tumor cells
Keywords: Nitric oxide; Topoisomerase II; VP-16; Doxorubicin; Cytotoxicity; Resistance;
Cancer TARGETases: DSB repair as a pharmacological target
Keywords: DSB repair; Genome instability; Cancer; Kinases; Helicases; Nucleases; ALT; alternative telomere lengthening; AML; acute myeloid leukemia; A-T; ataxia-telangiectasia; ATM; ataxia-telangiectasia mutated; ATP; adenosine triphosphate; ATR; ataxia-tel
Antiproliferative and apoptosis-inducing activities of novel naphthalimide-cyclam conjugates through dual topoisomerase (topo) I/II inhibition
Keywords: Naphthalimide-cyclam conjugates; Antitumor agents; Topoisomerase I; Topoisomerase II; DNA intercalation; Apoptosis;
Molecular modelling approach to evaluate poisoning of topoisomerase I by alternariol derivatives
Keywords: AOH; alternariol; AME; alternariol-methyl ether; ALT; altenuene; iALT; isoaltenuene; LBVS; ligand based virtual screening; Topo; topoisomerase; Topo I; topoisomerase I; Topo II; topoisomerase II; Molecular modelling; Alternaria metabolites; Alternariol; P
Inhibition of human topoisomerase I and II and anti-proliferative effects on MCF-7 cells by new titanocene complexes
Keywords: DMSO; dimethyl sulfoxide; THF; tetrahydrofuran; ADP; adenosine diphosphate; ATP; adenosine triphosphate; DAPI; 4â²,6-diamidino-2-phenylindole; DMEM/F-12; Dulbecco's modified eagle medium: nutrient mixture F-12; DNA; deoxyribonucleic acid; EDTA; ethylen
Design, synthesis and biological evaluation of novel 7-alkylamino substituted benzo[a]phenazin derivatives as dual topoisomerase I/II inhibitors
Keywords: Benzo[a]phenazin derivatives; Topoisomerase I; Topoisomerase II; ATPase catalytic inhibitor; Antitumor
Topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of dihydroxylated 2,6-diphenyl-4-aryl pyridines
Keywords: Dihydroxylated 2,6-diphenyl-4-aryl pyridines; Topoisomerase I; Topoisomerase II; Cytotoxicity; Anticancer agents;
Design and synthesis of dithiocarbamate linked β-carboline derivatives: DNA topoisomerase II inhibition with DNA binding and apoptosis inducing ability
Keywords: β-Carboline; Dithiocarbamate; Topoisomerase II; Anticancer activity; DNA-binding affinity; Pharmacophore;
Design, synthesis and biological evaluation of E-ring modified evodiamine derivatives as novel antitumor agents
Keywords: Evodiamine derivatives; Topoisomerase I; Topoisomerase II; Antitumor activity
Topoisomerase II inhibitors from the roots of Stellera chamaejasme L.
Keywords: BYRNGJPMZGEDAM-PYKMWLBDSA-NStellera chamaejasme L.; Cytotoxic activity; Topoisomerase II; Apoptosis
Synthesis, cytotoxicity, DNA binding and topoisomerase II inhibition of cassiarin A derivatives
Keywords: Cassiaria A; Amonafide; Selenium compound; DNA-binding; Topoisomerase II;
SAR analysis and biological studies of synthesized podophyllum derivates obtained by N linkage modification at C-4 position
Keywords: Podophyllum derivates; N linkage; SAR; Microtubule; Topoisomerase II;
A rational design strategy of the novel topoisomerase II inhibitors for the synthesis of the 4-O-(2-pyrazinecarboxylic)-4′-demethylepipodophyllotoxin with antitumor activity by diminishing the relaxation reaction of topoisomerase II-DNA decatenation
Keywords: Rational drug design strategy; 4′-Demethylepipodophyllotoxin derivates; Antitumor activity; Topoisomerase II; Cell cycle arrest; Apoptosis
Double-strand break repair and genetic recombination in topoisomerase and primase mutants of bacteriophage T4
Keywords: Bacteriophage T4; Double-strand break repair; RDR; Recombinational analysis; Genetic recombination; Gene 39; Gene 61; Topoisomerase II; Primase;
Design and synthesis of the novel DNA topoisomerase II inhibitors: Esterification and amination substituted 4′-demethylepipodophyllotoxin derivates exhibiting anti-tumor activity by activating ATM/ATR signaling pathways
Keywords: 4′-Demethylepipodophyllotoxin derivates; Anti-tumor activity; Topoisomerase II; Structure–activity relationships; Apoptosis; ATM/ATR signaling pathway
Discovery of dihydroxylated 2,4-diphenyl-6-thiophen-2-yl-pyridine as a non-intercalative DNA-binding topoisomerase II-specific catalytic inhibitor
Keywords: Topoisomerase I; Topoisomerase II; Cytotoxicity; Anticancer agents; Dihydroxylated 2,4-diphenyl-6-thiophen-2-yl-pyridines; 3D-QSAR
Synthesis, antitumor activity, and structure–activity relationship study of trihydroxylated 2,4,6-triphenyl pyridines as potent and selective topoisomerase II inhibitors
Keywords: Trihydroxylated 2,4,6-triphenyl pyridines; Topoisomerase I; Topoisomerase II; Topo II inhibitory activity; Cytotoxicity; Anticancer agents; Docking study
Synthesis and evaluation of 18F-labeled ATP competitive inhibitors of topoisomerase II as probes for imaging topoisomerase II expression
Keywords: Topoisomerase II; Catalytic inhibitors; Purine derivatives; Cytotoxicity; PET imaging; 18F-labelingDAST, diethylaminosulfur trifluoride; DCM, dichloromethane; DHP, dihydroyrane; DMF, dimethylformamide; DMSO, dimethylsulfoxide; ESI, electrospray ionization
Design, synthesis and systematic evaluation of cytotoxic 3-heteroarylisoquinolinamines as topoisomerases inhibitors
Keywords: 3-Heteroarylisoquinolinamine; Selective cytotoxicity; Topoisomerase I; Topoisomerase II; Molecular docking; Cell cycle arrest
Tetramethylpyrazine promotes SH-SY5Y cell differentiation into neurons through epigenetic regulation of Topoisomerase IIβ
Keywords: Ac-H3; acetylated histone H3; Ac-H4; acetylated histone H4; ChIP; chromatin immunoprecipitation; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethylsulfoxide; HATs; histone acetyltransferases; HDACs; histone deacetylases; MAP2; microtubule-associ
Structure-based design, synthesis and biological testing of etoposide analog epipodophyllotoxin-N-mustard hybrid compounds designed to covalently bind to topoisomerase II and DNA
Keywords: Boc2O; di-tert-butyl dicarbonate; CHO; Chinese hamster ovary; Et3N; triethylamine; EtOAc; ethyl acetate; HOBt; (1-hydroxybenzotriazole); ICE; immunodetection of complexes of enzyme-to-DNA; K562 cells; human erythroleukemic cells; kDNA; catenated DNA; MTS;
Synthesis, crystal structure and antiproliferative activity of Cu(II) nalidixic acid-DACH conjugate: Comparative in vitro DNA/RNA binding profile, cleavage activity and molecular docking studies
Keywords: Nalidixic acid; pBR322 DNA cleavage; Topo-II inhibition assay; U2OS cells; Molecular docking studies; UV-vis; UV-visible; ct-DNA; Calf thymus DNA; Topo II; Topoisomerase II; U2OS; Human osteoblastoma cell line;
Relationship of cellular topoisomerase IIα inhibition to cytotoxicity and published genotoxicity of fluoroquinolone antibiotics in V79 cells
Keywords: Fluoroquinolone; Clinafloxacin; Lomefloxacin; Topoisomerase II; Genotoxicity;
Synthesis and study of antiproliferative, antitopoisomerase II, DNA-intercalating and DNA-damaging activities of arylnaphthalimides
Keywords: Arylnaphthalimides; Antiproliferative activity; Topoisomerase II; DNA damage; Saccharomyces cerevisiae;
The discovery and optimization of novel dual inhibitors of topoisomerase ii and histone deacetylase
Keywords: Podophyllotoxin; HDAC; Topoisomerase II; Cancer; Hybrid; Synergistic effect;
Indenoindolone derivatives as topoisomerase II–inhibiting anticancer agents
Keywords: Indenoindolone; (Thio)semicarbazone; Oxime; Topoisomerase II; Anticancer agent
Naphthalimides exhibit in vitro antiproliferative and antiangiogenic activities by inhibiting both topoisomerase II (topo II) and receptor tyrosine kinases (RTKs)
Keywords: Angiogenesis; Multitarget; Naphthalimide; Topoisomerase II; Tyrosine kinaseEGFR, epidermal growth factor receptor; FGFR, fibroblast growth factor receptor; HMEC-1, Human Microvascular Endothelial Cells; kDNA, kinetoplast DNA; PDGFR, platelet-derived growt
Synthesis of novel naphthoquinone aliphatic amides and esters and their anticancer evaluation
Keywords: Anticancer activity; Cancer; Naphthoquinone aliphatic amide; Naphthoquinone aliphatic ester; Topoisomerase II
Synthesis and biological evaluation of novel 4β-(1,3,4-oxadiazole-2-amino)-podophyllotoxin derivatives
Keywords: Podophyllotoxin; 1,3,4-Oxadiazole; Antitumor activity; Topoisomerase II; Mechanism
A novel tetrahydrobenzoangelicin with dark and photo biological activity
Keywords: Tetrahydrobenzoangelicin; Antiproliferative activity; Photobiological activity; DNA interaction; Topoisomerase II;