کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1254699 | 971387 | 2014 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design, synthesis and biological evaluation of E-ring modified evodiamine derivatives as novel antitumor agents
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
A series of novel E-ring modified evodiamine derivatives were designed and synthesized as antitumor agents. Their capacity to interfere with the catalytic activity of topoisomerase I and II was evaluated by the relaxation assay. In vitro antitumor activity results revealed that compound 12 showed good antitumor activity with a broad spectrum. Its binding modes with topoisomerase I and II were clarified by molecular docking.
A series of novel E-ring modified evodiamine derivatives were designed and synthesized as antitumor agents. Compound 12 showed good antitumor activity with a broad spectrum, which acted by dual inhibition of topoisomerase I and II.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 25, Issue 7, July 2014, Pages 978–982
Journal: Chinese Chemical Letters - Volume 25, Issue 7, July 2014, Pages 978–982
نویسندگان
Kun Fang, Guo-Qiang Dong, Hai Gong, Na Liu, Zhen-Gang Li, Shi-Ping Zhu, Zhen-Yuan Miao, Jian-Zhong Yao, Wan-Nian Zhang, Chun-Quan Sheng,