کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1254699 971387 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design, synthesis and biological evaluation of E-ring modified evodiamine derivatives as novel antitumor agents
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Design, synthesis and biological evaluation of E-ring modified evodiamine derivatives as novel antitumor agents
چکیده انگلیسی

A series of novel E-ring modified evodiamine derivatives were designed and synthesized as antitumor agents. Their capacity to interfere with the catalytic activity of topoisomerase I and II was evaluated by the relaxation assay. In vitro antitumor activity results revealed that compound 12 showed good antitumor activity with a broad spectrum. Its binding modes with topoisomerase I and II were clarified by molecular docking.

A series of novel E-ring modified evodiamine derivatives were designed and synthesized as antitumor agents. Compound 12 showed good antitumor activity with a broad spectrum, which acted by dual inhibition of topoisomerase I and II.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 25, Issue 7, July 2014, Pages 978–982
نویسندگان
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